Gating with anatomically varying durations

ABSTRACT

A method for reconstructing a radioactive emission image of an overall volume having first and second volumetric regions, each volumetric region having respectively independent dynamic characteristics. The method comprises the following steps: a) obtaining radioactive emissions from the overall volume, including the volumetric regions, b) reconstructing an initial radioactive emission image of the volumetric region according to the radioactive emissions, c) segmenting the initial radioactive emission image to delineate the first and second volumetric regions, and d) separately reconstructing the first and the second volumetric regions according to the respectively independent dynamic characteristics.

RELATED APPLICATIONS

This application is a Continuation of U.S. patent application Ser. No.12/087,150, filed on Dec. 22, 2008 which is a National Phase of PCTPatent Application No. PCT/IL2006/001511 having International FilingDate of Dec. 28, 2006, which claims the benefit of U.S. ProvisionalPatent Application No. 60/816,970 filed on Jun. 28, 2006, 60/800,846filed on May 17, 2006, 60/800,845 filed on May 17, 2006, 60/799,688filed on May 11, 2006, 60/763,458 filed on Jan. 31, 2006, 60/754,199filed on Dec. 28, 2005.

U.S. patent application Ser. No. 12/087,150 is also a Continuation ofU.S. patent application Ser. No. 11/607,075 filed on Dec. 1, 2006 nowU.S. Pat. No. 8,094,894.

U.S. patent application Ser. No. 12/087,150 is also a Continuation ofPCT Patent Application No. PCT/IL2006/001291 having International FilingDate of Nov. 9, 2006, which also claims the benefit of U.S. ProvisionalPatent Application No. 60/800,846 filed on May 17, 2006, 60/800,845filed on May 17, 2006, 60/799,688 filed on May 11, 2006 and 60/754,199filed on Dec. 28, 2005.

U.S. patent application Ser. No. 12/087,150 is also a Continuation ofPCT Patent Application No. PCT/IL2006/000834 having International FilingDate of Jul. 19, 2006, which also claims benefit of U.S. ProvisionalPatent Application No. 60/816,970 filed on Jun. 28, 2006, 60/800,846filed on May 17, 2006, 60/800,845 filed on May 17, 2006, 60/799,688filed on May 11, 2006 and 60/763,458 filed on Jan. 31, 2006.

U.S. patent application Ser. No. 12/087,150 is also a Continuation ofPCT Patent Application No. PCT/IL2006/000840 having International FilingDate of Jul. 19, 2006, which also claims benefit of U.S. ProvisionalPatent Application No. 60/816,970 filed on Jun. 28, 2006, 60/800,846filed on May 17, 2006, 60/800,845 filed on May 17, 2006, 60/799,688filed on May 11, 2006 and 60/763,458 filed on Jan. 31, 2006.

U.S. patent application Ser. No. 12/087,150 is also a Continuation ofPCT Patent Application No. PCT/IL2006/000562 having International FilingDate of May 11, 2006, which also claims the benefit of U.S. ProvisionalPatent Applications No. 60/763,458 filed on Jan. 31, 2006.

U.S. patent application Ser. No. 12/087,150 is also a Continuation ofPCT Patent Application No. PCT/IL2006/000059 having International FilingDate of Jan. 15, 2006.

U.S. patent application Ser. No. 12/087,150 is also a Continuation ofU.S. patent application Ser. No. 12/084,559 filed on Nov. 26, 2008, nowU.S. Pat. No. 7,705,316 which is a National Phase of PCT PatentApplication No. PCT/IL2006/001291 having International Filing Date onNov. 9, 2006, which is a Continuation-in-Part (CIP) of PCT PatentApplication Nos. PCT/IL2006/000840 and PCT/IL2006/000834, both havingInternational Filing Date on Jul. 19, 2006, PCT/IL2006/000562 havingInternational Filing Date on May 11, 2006, PCT/IL2006/000059 havingInternational Filing Date on Jan. 15, 2006, PCT/IL2005/001215 havingInternational Filing Date on Nov. 16, 2005 and PCT/IL2005/001173 havingInternational Filing Date on Nov. 9, 2005.

PCT Patent Application No. PCT/IL2006/001291 also claims the benefit ofpriority of U.S. Provisional Patent Application No. 60/816,970 filed onJun. 28, 2006, 60/800,846 and 60/800,845, both filed on May 17, 2006,60/799,688 filed on May 11, 2006, 60/763,458 filed on Jan. 31, 2006,60/754,199 filed on Dec. 28, 2005, 60/750,597 and 60/750,334, both filedon Dec. 15, 2005, 60/750,287 filed on Dec. 13, 2005 and 60/741,440 filedon Dec. 2, 2005.

PCT Patent Application No. PCT/IL2006/001291 also claims the benefit ofpriority of Israel Patent Application No. 172349, filed on Nov. 27,2005.

PCT Patent Application No. PCT/IL2005/001173 is a Continuation-in-Part(CIP) of PCT Patent Application Nos. PCT/IL2005/000575 andPCT/IL2005/000572, both having International Filing Date on Jun. 1,2005, and PCT/IL2005/000048 having International Filing Date on Jan. 13,2005.

PCT Patent Application No. PCT/IL2005/001173 also claims the benefit ofpriority of U.S. Provisional Patent Application Nos. 60/720,652 and60/720,541, both filed on Sep. 27, 2005, 60/720,034 filed on Sep. 26,2005, 60/702,979 filed on Jul. 28, 2005, 60/700,753 and 60/700,752, bothfiled on Jul. 20, 2005, 60/700,318, 60/700,317, and 60/700,299 all filedon Jul. 19, 2005, 60/691,780 filed on Jun. 20, 2005, 60/675,892 filed onApr. 29, 2005, 60/648,690 filed on Feb. 2, 2005, 60/648,385 filed onFeb. 1, 2005, 60/640,215 filed on Jan. 3, 2005, 60/636,088 filed on Dec.16, 2004, 60/635,630 filed on Dec. 14, 2004, 60/632,515 filed on Dec. 3,2004, 60/632,236 filed on Dec. 2, 2004, 60/630,561 filed on Nov. 26,2004, 60/628,105 filed on Nov. 17, 2004 and 60/625,971 filed on Nov. 9,2004.

PCT Patent Application No. PCT/IL2005/001173 also claims the benefit ofpriority of Israel Patent Application No. 171346 filed on Oct. 10, 2005.

PCT Patent Application No. PCT/IL2005/000575 claims the benefit ofpriority of U.S. Provisional Patent No. 60/575,369 filed on Jun. 1,2004.

U.S. patent application Ser. No. 12/084,559 is also aContinuation-in-Part (CIP) of U.S. patent application Ser. No.11/034,007 filed on Jan. 13, 2005, now U.S. Pat. No. 7,176,466, whichclaims the benefit of priority of U.S. Provisional Patent ApplicationNo. 60/535,830 filed on Jan. 13, 2004.

The contents of the above applications are all incorporated herein byreference.

FIELD AND BACKGROUND OF THE INVENTION

The present invention relates to a method and an apparatus for imagereconstruction in nuclear medicine imaging and, more particularly, butnot exclusively to image reconstruction in nuclear medicine imagingusing gating techniques.

Radionuclide imaging aims at obtaining an image of a radioactivelylabeled substance, that is, a radiopharmaceutical, within the body,following administration, generally, by injection. The substance ischosen so as to be picked up by active pathologies to a different extentfrom the amount picked up by the surrounding, healthy tissue inconsequence; the pathologies are operative as radioactive-emissionsources and may be detected by radioactive-emission imaging. Pathologymay appear as a concentrated source of high radiation, that is, a hotregion, as may be associated with a tumor, or as a region of low-levelradiation, which is nonetheless above the background level, as may beassociated with carcinoma.

A reversed situation is similarly possible. Dead tissue has practicallyno pick up of radiopharmaceuticals, and is thus operative as a coldregion.

The mechanism of localization of a radiopharmaceutical in a particularorgan of interest depends on various processes in the organ of interestsuch as antigen-antibody reactions, physical trapping of particles,receptor site binding, removal of intentionally damaged cells fromcirculation, and transport of a chemical species across a cell membraneand into the cell by a normally operative metabolic process. A summaryof the mechanisms of localization by radiopharmaceuticals is found inhttp://www(dot)lunis(dot)luc(dot)edu/nucmed/tutorial/radpharm/i(dot)htm.

The particular choice of a radionuclide for labeling antibodies dependsupon the chemistry of the labeling procedure and the isotope nuclearproperties, such as the number of gamma rays emitted, their respectiveenergies, the emission of other particles such as beta or positrons, theisotope half-life, and the decay scheme.

In PET imaging, positron-emitting radioisotopes are used for labeling,and the imaging camera detects coincidence photons, the gamma pair of0.511 Mev, traveling in opposite directions. Each one of the coincidentdetections defines a line of sight, along which annihilation takesplace. As such, PET imaging collects emission events, which occurred inan imaginary tubular section enclosed by the PET detectors. A goldstandard for PET imaging is PET NH₃ rest myocardial perfusion imagingwith N-13-ammonia (NH₃), at a dose level of 740 MBq, with attenuationcorrection. Yet, since the annihilation gamma is of 0.511 Mev,regardless of the radioisotope, PET imaging does not provide spectralinformation, and does not differentiate between radioisotopes.

In SPECT imaging, primarily gamma emitting radioisotopes are used forlabeling, and the imaging camera is designed to detect the actual gammaemission, generally, in an energy range of approximately 11-511 KeV.Generally, each detecting unit, which represents a single image pixel,has a collimator that defines the solid angle from which radioactiveemission events may be detected.

Because PET imaging collects emission events, in the imaginary tubularsection enclosed by the PET detectors, while SPECT imaging is limited tothe solid collection angles defined by the collimators, generally, PETimaging has a higher sensitivity and spatial resolution than does SPECT.Therefore, the gold standard for spatial and time resolutions in nuclearimaging is defined for PET. For example, there is a gold standard forPET imaging for at rest myocardial perfusion with N-13-ammonia (NH₃), ata dose of 740 MBq with attenuation correction.”

Conventional SPECT cameras generally employ an Anger camera, in which asingle-pixel scintillation detector, such as NaI(Tl), LSO, GSO, CsI,CaF, or the like, is associated with a plurality of photomultipliers.Dedicated algorithms provide a two dimensional image of thescintillations in the single pixel scintillation detector. There areseveral disadvantages to this system, for example:

1. The dedicated algorithms associated with the single pixel cannotreach the accuracy of a two-dimensional image of a plurality of singlepixel detectors;

2. The single-pixel detector is a rigid unit, which does not have theflexibility of motion of a plurality of small detectors, each withindependent motion; and

3. A single hot spot may cause the single pixel detector of the Angercamera to saturate, whereas when a plurality of single pixel detectorsis employed, saturation is localized to a few pixels and does not affectthe whole image.

Other SPECT cameras which employ a plurality of single pixel detectorsare also known.

U.S. Pat. No. 6,628,984, to Weinberg, issued on Sep. 30, 2003 andentitled, “Handheld camera with tomographic capability,” describes atomographic imaging system, which includes a moveable detector ordetectors capable of detecting gamma radiation; one or more positionsensors for determining the position and angulation of the detector(s)in relation to a gamma ray emitting source; and a computational devicefor integrating the position and angulation of the detector(s) withinformation as to the energy and distribution of gamma rays detected bythe detector and deriving a three dimensional representation of thesource based on the integration. A method of imaging a radiationemitting lesion located in a volumetric region of interest also isdisclosed.

U.S. Pat. No. 6,242,743, to DeVito, et al., issued on Jun. 5, 2001 andentitled, “Non-orbiting tomographic imaging system,” describes atomographic imaging system which images ionizing radiation such as gammarays or x rays and which: 1) can produce tomographic images withoutrequiring an orbiting motion of the detector(s) or collimator(s) aroundthe object of interest, 2) produces smaller tomographic systems withenhanced system mobility, and 3) is capable of observing the object ofinterest from sufficiently many directions to allow multipletime-sequenced tomographic images to be produced. The system consists ofa plurality of detector modules which are distributed about or aroundthe object of interest and which fully or partially encircle it. Thedetector modules are positioned close to the object of interest therebyimproving spatial resolution and image quality. The plurality ofdetectors view a portion of the patient or object of interestsimultaneously from a plurality of positions. These attributes areachieved by configuring small modular radiation detector withhigh-resolution collimators in a combination of application-specificacquisition geometries and non-orbital detector module motion sequencescomposed of tilting, swiveling and translating motions, and combinationsof such motions. Various kinds of module geometry and module orcollimator motion sequences are possible, and several combinations ofsuch geometry and motion are shown. The geometric configurations may befixed or variable during the acquisition or between acquisitionintervals. Clinical applications of various embodiments of U.S. Pat. No.6,242,743 include imaging of the human heart, breast, brain or limbs, orsmall animals. Methods of using the non-orbiting tomographic imagingsystem are also included.

U.S. Pat. No. 5,939,724, to Eisen, et al., issued on Aug. 17, 1999, andentitled, “Light weight-camera head and—camera assemblies containingit,” describes a lightweight gamma-camera head, assemblies, and kitsthat embody it. The gamma-camera head has a detector assembly whichincludes an array of room temperature, solid state spectroscopy gradedetectors each associated with a collimator and preamplifier, whichdetectors and associated collimators and preamplifiers are arranged inparallel rows extending in a first direction and suitably spaced fromeach other in a second direction normal to the first direction, each ofthe parallel detector rows holding a plurality of detectors. The headmay optionally have an electric motor for moving the detector in thesecond direction and optionally also in the first direction, eitherstepwise or continuously.

U.S. Pat. No. 6,525,320, to Juni, issued on Feb. 25, 2003, and entitled,single photon emission computed tomography system, describes a singlephoton emission computed tomography system, which produces multipletomographic images of the type representing a three-dimensionaldistribution of a photon-emitting radioisotope. The system has a baseincluding a patient support for supporting a patient such that a portionof the patient is located in a field of view. A longitudinal axis isdefined through the field of view. A detector module is adjacent thefield of view and includes a photon-responsive detector. The detector isan elongated strip with a central axis that is generally parallel to thelongitudinal axis. The detector is operable to detect if a photonstrikes the detector. The detector can also determine a position alongthe length of the strip where a photon is detected. A photon-blockingmember is positioned between the field of view and the detector. Theblocking member has an aperture slot for passage of photons aligned withthe aperture slot. The slot is generally parallel to the longitudinalaxis. A line of response is defined from the detector through theaperture. A displacement device moves either the detector module or thephoton-blocking member relative to the other so that the aperture isdisplaced relative to the detector and the line of response is sweptacross at least a portion of the field of view.

U.S. Pat. No. 6,271,525, to Majewski, et al., issued on Aug. 7, 2001,and entitled, “Mini gamma camera, camera system and method of use,”describes a gamma camera, which comprises essentially and in order fromthe front outer or gamma ray impinging surface: 1) a collimator, 2) ascintillator layer, 3) a light guide, 4) an array of position sensitive,high resolution photomultiplier tubes, and 5) printed circuitry forreceipt of the output of the photomultipliers. There is also described,a system wherein the output supplied by the high resolution, positionsensitive photomultipiler tubes is communicated to: a) a digitizer andb) a computer where it is processed using advanced image processingtechniques and a specific algorithm to calculate the center of gravityof any abnormality observed during imaging, and c) optional imagedisplay and telecommunications ports.

U.S. Pat. No. 6,271,524, to Wainer, et al., issued on Aug. 7, 2001 andentitled, “Gamma ray collimator,” describes a gamma ray collimatorassembly comprising collimators of different gamma ray acceptanceangles. For example, the acceptance angle of a first collimator may bebetween 0.2 and 5 degrees, and the acceptance angle of a secondcollimator may be between about 5 and 30 degrees.

U.S. Pat. No. 6,212,423, to Krakovitz, issued on Apr. 3, 2001 andentitled, “Diagnostic hybrid probes,” describes a hybrid nuclear andultrasonic probe, comprising a cylindrical outer casing surrounding anuclear probe, which comprises two scintillator plates intersectingperpendicularly, each of the scintillator plates having a plurality ofparallel collimators; and an ultrasonic probe situated between saidcasing at the intersection of said scintillator plates.

List mode data acquisition is known in PET studies, and enables thedetermination of coincidence. It relates to recording every radiationevent together with data pertinent to that event, which includes:

i. the time the radiation event impinged upon a detector pixel, withrespect to a clock, with respect to a time bin, or with respect toanother time definition, for example, a time interval between two clocksignals; and

ii. the detector pixel location with respect to a coordinate system, atthe time of the impinging.

The knowledge of time and location enables the determination ofcoincidence counts, namely photon counts that arrive substantiallysimultaneously, 180 degrees apart.

The time and location data may be stamped onto the radiation-event datapacket, for example, as a header or as a footer, or otherwise associatedwith the radiation-event data packet, as known.

The time-stamped data available in PET studies may further be used forperfusion studies, where the timing of physiological processes of shortdurations, that is, durations shorter than about half the time spanbetween heartbeats, is important. Perfusion studies usually involve asequence of continuous acquisitions, each of which may represent dataacquisition duration of about 10-30 seconds, although longer durationsare sometimes employed. Data from each of the frames is independentlyreconstructed to form a set of images that can be visualized and used toestimate physiological parameters. This approach involves selection ofthe set of acquisition times, where one must choose between collectinglonger scans with good counting statistics but poor temporal resolution,or shorter scans that are noisy but preserve temporal resolution.

US Patent Application 2003010539, to Tumer, et al., published on Jun. 5,2003, and entitled, “X-ray and gamma ray detector readout system,”describes a readout electronics scheme, under development for highresolution, compact PET (positron emission tomography) imagers, usingtime tagging, based on LSO (lutetium ortho-oxysilicate,Lu.sub.2SiO.sub.5) scintillator and avalanche photodiode (APD) arrays.

There is some work relating to timing data in SPECT systems, employingAnger cameras.

U.S. Pat. No. 5,722,405, to Goldberg, issued on Mar. 3, 1998, andentitled, “Method and apparatus for acquisition and processsing of eventdata in semi list mode,” describes a system for acquisition, processingand display of gated SPECT imaging data for use in diagnosing CoronaryArtery Disease (CAD) in nuclear medicine, employing an Anger camera, andprovides a physician with two parameters for evaluating CAD: informationrelating to the distribution of blood flow within the myocardium(perfusion) and information relating to myocardium wall motion(function). One aspect provides the physician with a display offunctional images representing quantitative information relating to bothperfusion and function with respect to selected regions of interest ofthe subject heart at end-diastole and end-systole segments of thecardiac cycle. The functional display consists of arcs of varied widthdepending on wall motion and color coded to illustrate degrees ofmyocardial perfusion for different pie shaped sections of a selectedregion of interest within a given short axis slice of reconstructedvolumetric region data. Another aspect provides a series of displayimages allowing facilitated access, display, and comparison of thenumerous image frames of the heart that may be collected during gatedSPECT sessions. U.S. Pat. No. 5,722,405 also teaches the ability todefine and recall parameter files representative of data acquisition andprocessing parameters and protocol for use in gated SPECT studies andincludes a semi-list processing mode to increase efficiency of dataacquisition within a camera computer system.

U.S. Pat. No. 7,026,623, to Oaknin, et al., issued on Apr. 11, 2006, andentitled, “Efficient single photon emission imaging,” describes a methodof diagnostic imaging in a shortened acquisition time for obtaining areconstructed diagnostic image of a portion of a body of a human patientwho has been administered with dosage of radiopharmaceutical substanceradiating gamma rays, using SPECT and an Anger camera. The methodcomprises acquiring photons emitted from said portion of the body, bymeans of a detector capable of converting the photons into electricsignals, wherein the total time of photon acquiring is substantiallyshorter than the clinically acceptable acquisition time; processing saidelectric signals by a position logic circuitry and thereby deriving dataindicative of positions on said photon detector crystal, where thephotons have impinged the detector; and reconstructing an image of aspatial distribution of the pharmaceutical substance within the portionof the body by iteratively processing said data. For example, the methodincludes effective acquisition time of less than 10 minutes, or lessthan 8 minutes, and acquiring photons in a list-mode procedure.

Current techniques record data with SPECT and electrocardiogram (ECG),and perform some gating to the data which is captured by the SPECTdetectors, to incorporate the global and regional atrial and ventricularfunction and assessment of the relationship of perfusion to regionalfunction.

Gated images are used to overcome distortions such as motion artifacts,which are caused due to motion of the heart during image acquisition.The images are needed as the physical model used for reconstructionassumes that the imaged objects are static. In gated imaging,photon-counting takes into account the portion of the heart contractioncycle within which a photon is measured. The Gating enables thereconstruction of an anatomical structure which is subject to periodicmotion by enabling image acquisition only when the structure has reachedthe same configuration. Cardiac contraction is usually synchronized tothe recorded electrocardiogram (ECG) signal that indicates the currentheart pose. The period between a certain repetitive wave, such asR-wave, and a subsequent wave is divided into several time segments,called “frames”, which are usually spaced evenly. Each photon which isdetected by the PET detectors during one of the frames is collected andassociated with the related frame.

In gated imaging, each frame generates a single dataset. The collectionof all the datasets belonging to all the frames are defined as a“dynamic” dataset.

The dynamic dataset is created by dividing the time span between oneR-wave to the next R-wave into M frames that usually have an identicalduration. Each detected photon is accumulated into a dataset of one ofthe M frames. Each dataset of the M datasets contains data relevant to adefined portion (“snapshot”) within the cardiac cycle.

Usually, during the image reconstruction process, each one of the gateddatasets of the M frames is processed independently by a suitablereconstruction algorithm, see Leahy R et al., Computer tomography in:Handbook of Image and Video Processing, BovikA, Academic press, 2000,pp. 771-787; J. Kay. The EM algorithm in medical imaging, Stat. Meth.Med. Res., 6(1):55-75, January 1997; J. A. Fessler, Statistical imagereconstruction methods for transmission tomography, Handbook of MedicalImaging, Volumetric region 2, pages 1-70. SPIE, Bellingham, 2000; R. M.Leahy et al., Statistical approaches in quantitative positron emissiontomography, 10(2):147-65, April 2000; M. Defrise, A short reader's guideto 3D tomographic reconstruction, Computerized Medical Imaging andGraphics, 25(2):1 13-6, March 2001; Vandenberghe, Y. D'Asseler, et al.Iterative reconstruction algorithms in nuclear medicine, ComputerizedMedical Imaging and Graphics, 25(2):105-11, March 2001; G. L. Zeng.Image reconstruction, a tutorial, Computerized Medical Imaging andGraphics, 25(2):97-103, March 2001; and R. M. Lewitt et al., Overview ofmethods for image reconstruction from projections in emission computedtomography, Proc. IEEE, 91(9):1588-611, October 2003, which areincorporated herein by reference in its entirety.

A common practice in gated SPECT reconstruction is to divide the gateddynamic dataset into M ‘non-gated’ data sets. Each one of the datasetsincludes data from a single frame i. The reconstruction of eachvolumetric region is performed independently using the relevant dataset.

In particular, once the emission data is obtained, the data is processedto reconstruct the intensity distribution within the measured volumetricregion. The reconstruction process is generally complex, due to thelarge quantity of data that must be processed in order to obtain anaccurate reconstruction. The following prior art statistical model maybe used to perform reconstruction.

We assume an intensity distribution, I, defined over an input overallvolume U, where U denotes a set of basic elements, such as pixels in twodimensional overall volumes and voxels in three dimensional overallvolumes, and I(u) is the intensity of a given basic element u∈U. Adetecting unit positioned on a radiation-emission-measuring-probe suchas a PET detector or the like takes a series of measurementsy=(y_(t))_(t=1) ^(T) from different positions and orientations aroundthe volumetric region U. The geometrical and physical properties of thedetecting unit, together with its position and orientation in a givenmeasurement t, determine the detection probability ϕt(u) of a photonemitted from location u in time t. Thus, the effective intensity oflocation u as viewed by the detecting unit during measurement t isϕt(u)I(u).

The random count Xt(u) of photons that are emitted from location u anddetected in measurement t is modeled by a Poisson process with meanϕt(u)I(u). The total count of photons detected in measurement t isYt=Σu∈U Xt(u), and the reconstruction problem is to reconstruct theintensities (I(u))u∈U from the measurements (y_(t))_(t=1) ^(T).

The 2-D Radon transform is a mathematical relationship that may be usedfor reconstructing the emission intensities of volumetric region U whenthe set of measurements (y_(t))_(t=1) ^(T) is unconstrained. The Radontransform is not statistical and does not take into account thePoissonian nature of the counts. In addition, it models the views asline projections. The Radon transform maps the spatial domain (x,y) tothe Radon domain (p,ϕ). For a fixed projection angle, the Radontransform is simply a projection of the object. A technique known in theART as filtered back-projection (FBP) uses a back-projection operatorand the inverse of the Radon transform to reconstruct the intensitydistribution in volumetric region U from measurements (y_(t))_(t=1)^(T).

The basic, idealized problem solved by the FBP approach is toreconstruct an image from its Radon transform. The Radon transform, whenproperly defined, has a well-defined inverse. However, in order toinvert the transform one needs measured data spanning 180°. In manymedical imaging situations, the positioning of the detecting unitrelative to the emitting object is constrained, so that completemeasured data is not available. Reconstruction based on filteredback-projection is therefore of limited use for medical imaging. Maximumlikelihood (ML) and Maximum A Posteriori (MAP) estimation methods, whichaddress the statistical nature of the counts, have been found to providebetter image reconstructions than FBP.

Limited-angle tomography is a reconstruction technique in the relatedart which reconstructs an image from projections acquired over a limitedrange of angular directions. The success of the reconstruction processdepends upon the extent of the angular range acquired compared with theangular range of the missing projections. Any reconstruction from alimited range of projections potentially results in spatial distortions(artifacts) in the image. Limited angle techniques can be applied forboth the Radon transform and the statistical models, but better resultsare generally achieved within the statistical framework. While it isknown that the severity of the artifacts increases with the increasingangular range of the missing projections, limited-angle tomography doesnot provide information on which projections should be used in order tomost effectively reconstruct the image.

ML estimation is a widely used method in the related art forreconstructing an image from a constrained set of measurements. Aparameterization of the generative model described above is obtained byassigning an intensity I(u) to every voxel in U. The likelihood of theobserved data y=(yt)t, given the set of parameters I={I(u):u∈U} is:

$\begin{matrix}{\begin{matrix}{{L\left( {y❘I} \right)} = {{\ln\;{P\left( {y❘I} \right)}} = {{\ln{\prod\limits_{t}{P\left( {y_{t}❘I} \right)}}} = {\sum\limits_{t}{\ln\;{P\left( {{\sum\limits_{u}{x_{t}(u)}}❘I} \right)}}}}}} \\{= {\sum\limits_{t}{\ln\mspace{14mu}{{Poisson}\left( {y_{t}❘{\sum\limits_{u}{{\phi_{t}(u)}{I(u)}}}} \right)}}}} \\{= {\sum\limits_{t}\begin{Bmatrix}{{- {\sum\limits_{u}{{\phi_{t}(u)}I(u)}}} +} \\{{y_{t}\ln{\sum\limits_{u}{{\phi_{t}(u)}{I(u)}}}} - {\ln\left( {y_{t}!} \right)}}\end{Bmatrix}}}\end{matrix}\quad} & (1)\end{matrix}$

Note that the lower and upper bound of an indexing variable, such asvoxels u and time index t, are omitted in the following description,when they are clear from the context.

There is currently no analytic way to solve Eqn. 1 for the maximum ofthe likelihood function. However, optimization methods that find localmaxima of the likelihood are known. One such method is theExpectation-Maximization (EM) process.

Since the data generated by the model is only partially observable byour measurements, a basic ingredient of the EM formalism is to define aset of random variables that completely define the data generated by themodel. In the current case, since Yt=ΣuXt(u), the set of variables{Xu(t):u∈U; t=1, . . . , T} is such a set; the generated data isx=(xt)t, where xt=(xt(u))u, and the observed data y is completelydetermined by x. The main tool in the EM formalism is the complete datalikelihood:

$\begin{matrix}{\begin{matrix}{{\ln\;{P\left( {x❘I} \right)}} = {{\ln{\prod\limits_{t}{P\left( {x_{t}❘I} \right)}}} = {\sum\limits_{t}{\ln{\prod\limits_{u}{{Poisson}\left( {{x_{t}(u)}❘{{\phi_{t}(u)}{I(u)}}} \right)}}}}}} \\{= {\sum\limits_{t}{\sum\limits_{u}\left\{ {{{- {\phi_{t}(u)}}{I(u)}} + {{x_{t}(u)}{\ln\left( {{\phi_{t}(u)}{I(u)}} \right)}} + {\ln\left( {{x_{t}(u)}!} \right)}} \right\}}}}\end{matrix}{\quad\quad}} & (2)\end{matrix}$

Since the likelihood depends on the complete data, which is onlypartially observable, we take its expectation with respect to theoverall volume of the unobserved data, given the current set ofhypothesized parameters (i.e. the current estimator). The result is afunction Q(I|I′) which assigns likelihood to sets I of model parameters,given the current set I′, and given the observed data y:

$\begin{matrix}{\begin{matrix}{{Q\left( {I❘I^{\prime}} \right)} = {E\left\lbrack {{\ln\;{P\left( {x❘I} \right)}y};I^{\prime}} \right\rbrack}} \\{= {\sum\limits_{t}{\sum\limits_{u}\left\{ {{{- {\phi_{t}(u)}}{I(u)}} + {{E\left\lbrack {{{x_{t}(u)}❘y_{t}};I^{\prime}} \right\rbrack}{\ln\left( {{\phi_{t}(u)}{I(u)}} \right)}} + C} \right\}}}}\end{matrix}\quad} & (3)\end{matrix}$

where C is a term which is independent of the intensities I. Thefunction Q(I|I′) is maximized by the following new estimates:

$\begin{matrix}{{{{I(u)} = {\frac{1}{\sum_{t}{\phi_{t}(u)}}{\sum\limits_{t}\left\lbrack {{{x_{t}(u)}❘y_{t}};I^{\prime}} \right\rbrack}}};}{\forall{u \in {U.}}}} & (4)\end{matrix}$

The expectation in Equation 4 is obtained as follows:

$\begin{matrix}\begin{matrix}{{P_{X_{t}{(u)}}\left( {{{x_{t}(u)}❘y_{t}};I^{\prime}} \right)} = \frac{{P_{Y_{t}}\left( {{y_{t}❘{x_{t}(u)}};I^{\prime}} \right)}\mspace{11mu}{P_{X_{t}{(u)}}\left( {{x_{t}(u)}❘I^{\prime}} \right)}}{P_{Y_{\tau}}\left( {y_{t}❘I^{\prime}} \right)}} \\{= \frac{\begin{matrix}{{Poisson}\left( {{y_{t} - {x_{t}(u)}}❘{\sum\limits_{v \neq u}{{\phi_{t}(v)}{I^{\prime}(v)}}}} \right)} \\{{Poisson}\left( {{x_{t}(u)}❘{{\phi_{t}(u)}{I^{\prime}(u)}}} \right)}\end{matrix}}{{Poisson}\;\left( {y_{t}❘{\sum\limits_{v}{{\phi_{t}(v)}{I(v)}}}} \right)}} \\{= {{Binomial}\left( {{{x_{t}(u)}❘\frac{{\phi_{t}(u)}{I^{\prime}(u)}}{\sum\limits_{v}{{\phi_{t}(v)}{I^{\prime}(v)}}}};y_{t}} \right)}}\end{matrix} & (5)\end{matrix}$

It follows that

${{E\left\lbrack {{{{xt}(u)}❘{yt}};I^{\prime}} \right\rbrack} = {y_{t}\frac{{\phi_{t}(u)}{I^{\prime}(u)}}{\sum\limits_{v}{{\phi_{t}(v)}{I^{\prime}(v)}}}}},$and hence the EM iteration is:

$\begin{matrix}{{I(u)} = {\frac{1}{\sum\limits_{t}{\phi_{t}(u)}}{\sum\limits_{t}{y_{t}\frac{{\phi_{t}(u)}{I^{\prime}(u)}}{\sum\limits_{v}{{\phi_{t}(v)}{I^{\prime}(v)}}}}}}} & (6)\end{matrix}$

It is provable that each EM iteration improves the likelihood. Thus,given a random starting estimator, the EM algorithm iterates the aboveimprovement step until it converges to a local maximum of thelikelihood. Several random starts increase the chance of finding aglobally good estimator.

It is usually desired to maximize the expected posterior probability(given a proper prior) rather than the expected likelihood. In that casewe assume a prior probability on the intensities P(I)=ΠuP(I(u)). Aproper conjugate prior for the Poisson distribution is the Gammadistribution:

$\begin{matrix}{{P\left( {I(u)} \right)} = {{{Gamma}\left( {{{I(u)}❘\alpha_{u}};\beta_{u}} \right)} = {\frac{\beta_{u}^{\alpha_{u} + 1}}{\Gamma\left( {\alpha_{u} + 1} \right)}{I(u)}^{\alpha_{u}}e^{{- \beta_{u}}{I{(u)}}}}}} & (7)\end{matrix}$

Now the maximization is done on Q(I|I′)=E[lnP(x|I)p(I)|y; I′]. Pluggingthe Gamma prior into Q, and solving for I(u), we get the following EMiteration for the maximum posterior estimation:

$\begin{matrix}{{I(u)} = {\frac{\alpha_{u} + {\sum\limits_{t}{E\left\lbrack {{{x_{t}(u)}❘y_{t}};I^{\prime}} \right\rbrack}}}{\beta_{u} + {\sum{\phi_{t}(u)}}}\mspace{365mu}(8)}} \\{= {{\frac{1}{\beta_{u} + {\sum\limits_{t}{\phi_{t}(u)}}}\left\lbrack {\alpha_{u} + {\sum\limits_{t}{y_{t}\frac{{\phi_{t}(u)}{I^{\prime}(u)}}{\sum\limits_{v}{{\phi_{t}(u)}{I^{\prime}(v)}}}}}} \right\rbrack}\mspace{205mu}(9)}}\end{matrix}$

The EM update step can be formulated in matrix notation as follows. LetΦ be the matrix of the projections [ϕt(u)]t,u, and let I, I′,y, α and βbe represented as column vectors. Equation 8 can be written in vectorand matrix notations as:

$\begin{matrix}{I = \frac{\alpha + {I^{\prime} \cdot \left( {\Phi^{T}\frac{y}{\Phi\; I^{\prime}}} \right)}}{\beta + {\Phi^{T}\; 1}}} & (10)\end{matrix}$

where the explicit multiplication and division denote element-wiseoperations, and where 1 is a vector (of the appropriate length)consisting solely of 1's.

Limited computational resources (i.e., when the entire projection matrixΦ cannot be kept in memory) may require breaking the update computationaccording to a partition of Φ into a set of sub-matrices (Φi). In thatcase the intensities can be updated gradually (using only one sub-matrixat each step) according to the following computation:

$\begin{matrix}{I = \frac{\alpha + {I^{\prime} \cdot {\sum\limits_{i}{\Phi_{i}^{T}\frac{y_{i}}{\Phi_{i}I^{\prime}}}}}}{\beta + {\sum\limits_{i}{\Phi_{i}^{T}\mspace{11mu} 1}}}} & (11)\end{matrix}$

where yi denotes the vector of observations that are obtained using theviews of Φi.

In order to achieve a reconstructed image which is adequate for medicaldiagnostic and treatment purposes, a high-resolution image of the testedobject must be obtained. When high-resolution detecting units are used,their efficiency is relatively low, and the detecting units must remainat each position for a relatively long time in order to achieve a highprobability of detection. Since during medical testing, measurements aregenerally performed at many locations as the detecting unit is movedrelative to the observed organ, the testing procedure generally requiresa long time and is physically and emotionally difficult for the patient.Additionally, reconstruction is based upon a large quantity of data, andis a lengthy and computationally complex process.

Reference is now made to FIG. 13, which is a schematic flowchart thatillustrates steps of a typical prior art gated image reconstructionmethod. In FIG. 13, i denotes a frame counter and M denotes the numberof frames. Usually, after all the M datasets are fetched, as shown at 2,and i is set with 1, as shown at 4, the dataset that corresponds withframe i is loaded into the processing unit, as shown at 6. During thefollowing step, as shown at 8, the processing unit is used to perform aframe reconstruction according to the dataset that corresponds withframe i using any suitable reconstruction algorithm known in the art,such as the aforementioned EM algorithm, ordered subset expectationmaximization (OSEM), and algebraic reconstruction techniques (ART) FBP.

As shown at 12, after the reconstruction is completed, the frame counteri is incremented by 1. If i is larger than M and there are no more framethe process ends. If i is not larger than M, the next dataset thatcorresponds with the subsequent frame is loading for reconstruction. Insuch a manner, the generation of a static imaging of the heart in aspecific configuration becomes possible.

However, a known problem of such a method is the high computational loadthat is needed for the execution thereof. Even when using an ordered setmethod, such as the aforementioned Hudson et al. method, which iscapable of reducing the computational load while giving similar results,the computational power needed to obtain a good image reconstruction isstill quite high. Such a high computational load results in a longerreconstruction time that reduces the throughput of the processing unitand requires a more expensive processing hardware.

There is thus a widely recognized need for, and it would be highlyadvantageous to have, a method and an apparatus for image reconstructionin nuclear medicine imaging devoid of the above limitations.

SUMMARY OF THE INVENTION

According to one aspect of the present invention there is provided amethod for iteratively reconstructing a volumetric image of an overallvolume from radioactive emissions, the method comprising:

a) obtaining radioactive emissions from the overall volume, the overallvolume comprising at least a part of a body organ or other body portion;

b) using the radioactive emissions to reconstruct an initial volumetricimage of the overall volume, the initial volumetric image containing aninitial location and initial shape of the at least a part of a bodyorgan or other body portion and an initial estimation of number ofphotons emitted from the at least a part of a body organ or other bodyportion; and

c) reconstructing a further volumetric image from the initial volumetricimage by an iterative process using object implantation for refiningreconstruction, wherein the object implantation includes:

providing a model of at least a portion of the overall volume, the modelincluding a general location and shape of the at least a part of a bodyorgan or other body portion and an expected number of photons emittedfrom the at least a part of a body organ or other body portion;

replacing, at the general location, at least a portion of the initialvolumetric image with the general shape of the at least a part of a bodyorgan or other body portion, based on the model;

determining an improved estimation of a number of photons emitted fromthe at least a portion of the initial volumetric image, based on theexpected number of photons, wherein the improved estimation is anincrease in number of photons over the initial estimation; and

replacing the initial estimation of number of photons with the improvedestimation, wherein the object implantation is used one or more timesduring the iterative process, each time for providing a better startingpoint for performing a next iteration of the iterative process, wherebythe improved estimation is used to redistribute photon counts in aniteration.

Unless otherwise defined, all technical and scientific terms used hereinhave the same meaning as commonly understood by one of ordinary skill inthe art to which this invention belongs. The materials, methods, andexamples provided herein are illustrative only and not intended to belimiting.

Implementation of the method and system of the present inventioninvolves performing or completing certain selected tasks or stepsmanually, automatically, or a combination thereof. Moreover, accordingto actual instrumentation and equipment of preferred embodiments of themethod and system of the present invention, several selected steps maybe implemented by hardware or by software on any operating system of anyfirmware or a combination thereof. For example, as hardware, selectedsteps of the invention may be implemented as a chip or a circuit. Assoftware, selected steps of the invention may be implemented as aplurality of software instructions being executed by a computer usingany suitable operating system. In any case, selected steps of the methodand system of the invention may be described as being performed by adata processor, such as a computing platform for executing a pluralityof instructions.

BRIEF DESCRIPTION OF THE SEVERAL VIEWS OF THE DRAWINGS

The patent or application file contains at least one drawing executed incolor. Copies of this patent or patent application publication withcolor drawings will be provided by the Office upon request and paymentof the necessary fee.

The invention is herein described, by way of example only, withreference to the accompanying drawings. With specific reference now tothe drawings in detail, it is stressed that the particulars shown are byway of example and for purposes of illustrative discussion of thepreferred embodiments of the present invention only, and are presentedin order to provide what is believed to be the most useful and readilyunderstood description of the principles and conceptual aspects of theinvention. In this regard, no attempt is made to show structural detailsof the invention in more detail than is necessary for a fundamentalunderstanding of the invention, the description taken with the drawingsmaking apparent to those skilled in the art how the several forms of theinvention may be embodied in practice.

In the drawings:

FIGS. 1A-1D schematically illustrate a dynamic SPECT camera, inaccordance with embodiments of the present invention;

FIGS. 2A and 2B schematically illustrate the camera structure with theassemblies, in accordance with an embodiment of the present invention.

FIGS. 3A-3D schematically illustrate viewing positions, in accordancewith embodiments of the present invention.

FIGS. 4A-4F schematically illustrate stereo views and cross views, inaccordance with embodiments of the present invention.

FIGS. 5A and 5B illustrate experimental radiopharmaceutical data, asknown;

FIGS. 5C-5F illustrate cardiac gating, in accordance with embodiments ofthe present invention;

FIG. 6A-6I illustrate an intracorporeal dynamic SPECT camera, inaccordance with embodiments of the present invention;

FIG. 7 illustrates assembly-damping parameters, in accordance withembodiments of the present invention;

FIGS. 8A and 8B schematically illustrate grid and anatomicalconstruction of voxels, in accordance with embodiments of the presentinvention;

FIGS. 9A-9J present experimental data, obtained by the dynamic SPECTcamera, in accordance with embodiments of the present invention;

FIG. 10 presents experimental data, obtained by the dynamic SPECTcamera, in accordance with embodiments of the present invention;

FIG. 11 illustrates components of the dynamic SPECT camera, inaccordance with embodiments of the present invention;

FIG. 12 illustrates an electrical scheme, in accordance with embodimentsof the present invention;

FIG. 13 is a schematic flowchart that illustrates steps of a typicalprior art gated image reconstruction method;

FIG. 14 is a schematic illustration of an apparatus for reconstructing aradioactive emission image of an input overall volume having dynamic andstatic volumetric regions, according to a preferred embodiment ofpresent invention;

FIG. 15 is a schematic isometric view of the input overall volume thatis depicted in FIG. 14, according to one embodiment of the presentinvention;

FIG. 16 is a schematic cross-sectional view of the input overall volumeof FIG. 15, according to one embodiment of the present invention;

FIG. 17 is a flowchart that depicts a method for reconstruction an inputoverall volume using anatomically varying time-bin lengths, according toone embodiment of the present invention;

FIG. 18 is a graphical representation of a one-dimensional vector ofvoxels that represents the reconstruction of the input overall volume,according to one embodiment of the present invention;

FIG. 19 is another flowchart that depicts another method forreconstruction an input overall volume using anatomically varyingtime-bin lengths, according to another embodiment of the presentinvention; and

FIG. 20 is a graphical representation of a position of two selectedsub-regions in two sequential frames, according to another embodiment ofthe present invention.

DESCRIPTION OF SPECIFIC EMBODIMENTS OF THE INVENTION

The present invention relates to an apparatus and a method forreconstructing a radioactive emission image of a overall volume havingdynamic and static volumetric regions. The reconstructing is based ongated images with anatomically varying time-bin lengths. The apparatusand the method are designed to allow the segmentation of the radioactiveemission image to gated and non-gated regions. In such a manner, thereconstructions radioactive emissions from the dynamic volumetric regionand the static volumetric region are carried out separately. Thus, thehigh computational throughput that is needed in order to reconstruct adynamic volumetric region, such as the heart, using time binningtechniques has less or no effect on the reconstruction of the staticvolumetric region, as further described below. The disclosed apparatuscomprises a number of detectors, such as PET or SPECT detectors, whichare designed for obtaining radioactive emissions from the overall volumeand an image reconstruction module that is designed for generatingradioactive emission images of the overall volume according to theobtained radioactive emissions. The apparatus further comprises asegmentation module that is designed for segmenting an initialradioactive emission image to gated and non-gated regions, according tothe dynamic and static volumetric regions of the overall volume. Theimage reconstruction module is designed to reconstruct separately thegated and non-gated regions in the radioactive emission imagerespectively according to radioactive emissions the dynamic and staticvolumetric regions.

The method for reconstructing a radioactive emission image of a overallvolume having static and dynamic volumetric regions comprises severalsteps. During the first step, radioactive emissions are obtained fromthe overall volume. Then, an initial radioactive emission image of theoverall volume is reconstructed according to the radioactive-emissiondata. In the following step, the initial radioactive emission image issegmented to gated and non-gated regions, respectively according to thedynamic and static volumetric regions. During the last step, theradioactive emission image is reconstructed, wherein the gated region isaccording to radioactive emissions from said dynamic volumetric regionand the non-gated region is separately reconstructed according toradioactive emissions from the static volumetric region.

In another embodiment, only the dynamic volumetric region isreconstructed using time binning. The static volumetric region isreconstructed according to the initial radioactive emission image.Preferably, time binning of different anatomical segments hasdynamically varying time-bin lengths, as further described below.

The principles and operation of the dynamic SPECT camera according toaspects of the present invention may be better understood with referenceto the drawings and accompanying descriptions.

The principles and operation of an apparatus and method according to thepresent invention may be better understood with reference to thedrawings and accompanying description.

Before explaining at least one embodiment of the invention in detail, itis to be understood that the invention is not limited in its applicationto the details of construction and the arrangement of the components setforth in the following description or illustrated in the drawings. Theinvention is capable of other embodiments or of being practiced orcarried out in various ways. Also, it is to be understood that thephraseology and terminology employed herein is for the purpose ofdescription and should not be regarded as limiting.

Reference is now made to FIG. 14, which is a schematic illustration ofan apparatus 990 for reconstructing a radioactive emission image of aninput overall volume 1002 having dynamic 1003 and static 1002 volumetricregions, according to a preferred embodiment of present invention. Inone embodiment of the present invention, the input overall volume 1002is the thorax, the static volumetric region is the related viscus, andthe dynamic volumetric region is the heart and the area that confinesit. The apparatus 990, which is preferably a SPECT camera, has a numberof detecting units 993, such as SPECT detectors. Each one of thedetectors 993 is designed for obtaining radiation emission that isemitted from the input overall volume 1002, as described below, and forgenerating accordingly radioactive-emission data. The apparatus 990comprises an image reconstruction module 992 that is connected to thedetecting units 993. The image reconstruction module 992 is designed forgenerating radioactive emission images according to theradioactive-emission data. The images are preferably gated, as describedbelow. The apparatus 990 further comprises a segmentation module 991that is designed for segmenting an initial radioactive emission image,which has been generated by the image reconstruction module 992, togated and non-gated regions according to the dynamic and staticvolumetric regions. The gated and non-gated regions are used by theimage reconstruction module 992 for separately reconstructing thedynamic and static volumetric regions, as further described below in theanatomically varying time-bin lengths section.

Reference is now made to a more elaborated description of a preferredapparatus 990.

Dynamic Spect Camera

Design Description of the Dynamic SPECT Camera

As described above, in one embodiment of the present invention theapparatus 990 is a dynamic SPECT camera. Hereinbelow a description of adynamic SPECT camera with temporal and spatial resolutions, which meetand even outperforms those of PET, and with a high spectral resolutionnot available in PET is given.

Temporal resolution, as used herein, relates to a minimal acquisitiontime for a tomographic reconstruction image of a predeterminedvolumetric region, for example 15×15×15 cubic centimeters, andpredetermined spatial resolution, for example, 10×10×10 cubicmillimeters. The minimal acquisition time may be, for example, 30seconds, 10 seconds, or 1 second.

Reference is now made to FIGS. 1A-1D, which schematically illustrate adynamic SPECT camera 10 that is configured for capturing gated imagesand non-gated image, in accordance with embodiments of the presentinvention. The dynamic SPECT camera 10 comprises: an overall structure15, which defines proximal and distal ends and, with respect to a body100; a number of assemblies 20, for example, 6, 9, or 16 assemblies 20,arranged on the overall structure 15, forming an array 25 of theassemblies 20. Each one the each assemblies 20 comprises a number ofdetecting units 12. Each detecting unit 12 includes a single-pixeldetector 14 for detecting radioactive emissions and a dedicatedcollimator 16, attached to the single-pixel detector 14, at the proximalend thereof, for defining a solid collection angle δ for the detectingunit 12.

Additionally, each assembly 20 comprises an assembly motion provider 40,configured for providing the assembly 20 with individual assemblymotion, with respect to the overall structure 15, during the acquisitionof radioactive-emission data for a tomographic image.

The dynamic SPECT camera 10 further includes a timing mechanism 30, incommunication with each single-pixel detector 14, configured forenabling time binning of the radioactive emissions impinging upon eachsingle-pixel detector 14 to periods, which are not greater thansubstantially 30 seconds. As the timing mechanism 30 has can controleach one of the single-pixel detector 14 separately, each one of thesingle-pixel detectors 14 can be configured according to a differenttime binning scheme. In one embodiment of the present invention, thetime binning scheme, which is applied to a certain detector, isdetermined according to the region in the input overall volume that thedetector is designed to detect.

The dynamic SPECT camera 10 further includes a position tracker 50,which is designed for providing information on the position andorientation of each detecting unit 12, with respect to the overallstructure 15, substantially at all times, during the individual assemblymotion.

The dynamic SPECT camera 10 is configured for acquiring a tomographicreconstruction image of a region of interest of about 15×15×15 cubiccentimeters, for example, of a target organ 110, such as a heart or astomach, during an acquisition period no greater than 300 seconds, at aspatial resolution of at least 10×10×10 cubic millimeters.

It will be appreciated that the time period may be no greater than 200seconds, 100 seconds, 60 seconds, 30 seconds, 10 seconds, or 1 second.

Additionally, the dynamic SPECT camera 10 is configured for acquiring aseries of tomographic reconstruction images of a region of interest, asa function of time, at a rate of at least a tomographic reconstructionimage every 300 seconds.

Again, the rate may further be every 200 seconds, 100 seconds, 60seconds, 30 seconds, 10 seconds, or 1 second.

In accordance with embodiments of the present invention, the individualassembly motion may be, for example, an assembly oscillatory sweepingmotion, as described by an arrow 60. Additionally or alternatively, theindividual assembly motion may be a first oscillatory lateral motion, asdescribed by an arrow 80. Additionally or alternatively, the individualassembly motion may be a second oscillatory lateral motion, orthogonalto the first, as described by an arrow 90. Thus, the assembly motionprovider 40 may comprise between one and three motion providing units,for the different assembly motions.

Alternatively, the individual assembly motion is an assembly oscillatorysweeping motion, as described by an arrow 60, while the array 25 moveswith either the first or the second oscillatory lateral motions,described by the arrows 80 and 90, or with both.

Additionally, the detecting units 12 may be grouped into square orrectangular blocks 18, for example, of 4×4 detecting units 12, as seenin FIG. 1A, or of 16×16, 64×64, 64×128 or another number of detectingunits 12. Furthermore, the blocks 18 may be provided with individualblock oscillatory sweeping motion, as described by an arrow 70, withrespect to the overall structure 15, during the acquisition ofradioactive-emission data for a tomographic image. Preferably, the blockoscillatory sweeping motion is orthogonal to, or at an angle to theassembly oscillatory sweeping motion, described by the arrow 60. Thus,the assembly motion provider 40 may further comprise a dedicated blockmotion providing unit, in communication with each block of an assembly.

A control unit 55 may be integrated with the dynamic SPECT camera 10, toform a single physical unit, or in communication with the dynamic SPECTcamera 10.

A spectral selection mechanism 56, in communication with each of thedetecting unit 12, is discussed hereinbelow, under the heading,“dynamically varying spectral bins.”

The body 100 may be a human or an animal, and the region of interest, orthe target organ 110 may be a heart, a brain, a breast, a stomach, a GItract, a colon, a prostate, a uterus, a cervix, a vagina, a throat, agland, a lymph node, a portion of skin, a portion of bone, portion ofanother tissue, or another body portion.

As seen in FIGS. 1A and 1B, a reference x;y;z coordinate systemillustrates a preferred orientation of the dynamic SPECT camera 10 withrespect to the body 100, wherein z runs along a length of the body 100.For convenience, the assembly axis along the assembly length will bereferred to as the assembly longitudinal axis, and the assembly axisalong the assembly width will be referred to as the assembly traverseaxis.

Preferably, the assemblies 20 are long and narrow columns, arrangedlongitudinally against the body 100, wherein the oscillatory sweepingmotion, described by an arrow 60, is about the z-axis. It will beappreciated that other arrangements are similarly possible.

As seen in FIG. 1C, illustrating a cross-sectional view in the x-yplane, preferably, the assemblies 20 are arranged in an arc or anarc-like structure, about the body 100, maintaining a shape that followsthe body contours, so as to keep as close as possible to the body 100.

FIG. 1D provides details of the detecting unit 12. The collimator has alength L, a collection angle δ, and a septa thickness τ. The singlepixel detector is preferably a square of sides D and a detectorthickness τd.

Preferred dimensions for the detecting unit 12 may be, for example, 2.46mm×2.46 mm, and the solid collection angle δ may be at least 0.005steradians. Generally, there may be 16×64 detecting units 12 per block18.

The detector 14 is preferably, a room temperature, solid-state CdZnTe(CZT) detector, which is among the more promising that is currentlyavailable. It may be obtained, for example, IMARAD IMAGING SYSTEMS LTD.,of Rehovot, ISRAEL, 76124, www(dot)imarad(dot)com, or from eV Products,a division of II-VI Corporation, Saxonburg Pa., 16056, or from or fromanother source. Alternatively, another solid-state detector such asCdTe, HgI, Si, Ge, or the like, or a combination of a scintillationdetector (such as NaI(Tl), LSO, GSO, CsI, CaF, or the like) and aphotomultiplier, or another detector as known, may be used, preferablywith a photomultiplier tube for each single-pixel detector 14 andcollimator 16, for accurate spatial resolution.

Reference is further made to FIGS. 2A and 2B that schematicallyillustrate the structure 15 with the assemblies 20, in accordance withan embodiment of the present invention. As seen, the assemblies 20 arearranged in an arc of an angle α, around the body 100, and move in theassembly oscillatory sweeping motion, about the z-axis, so as to providea plurality of views of the heart 110, from many positions, along thex-y plane.

As seen in FIGS. 2A and 2B, the dynamic camera 10 is configured forsimultaneous acquisition by the assemblies 20, each scanning the sameregion of interest from a different viewing position, thus achievingboth shorter acquisition time and better edge definitions.

Preferably, the structure 15 conforms to the contours of the body 100,to maintain substantial contact or near contact with the body.

The embodiment of FIGS. 2A and 2B illustrates a single type ofmotion-assembly oscillatory sweeping motion about the z-axis, asdescribed by the arrow 60 (FIG. 1A). In some cases, additional motionsor views from additional directions may be desirous, as illustrated inFIGS. 3A-3D, hereinbelow.

Reference is further made to FIGS. 3A-3D, which schematically illustrateviewing positions, in accordance with embodiments of the presentinvention.

FIG. 3A illustrates a cylindrical target organ 110, with a cylindricalradioactive emission source 115 therein.

As seen in FIG. 3B, a view along the x-axis will observe the cylindricalradioactive emission source 115 as a bar 115.

As seen in FIG. 3C, a view along the y-axis will similarly observe thecylindrical radioactive emission source 115 as a bar 115, thus notadding new information to the view along the x-axis.

It will be appreciated that in the present example, any view along thex-y plane will observe the radioactive emission source 115 as a bar 115.

As seen in FIG. 3D, a view along the z-axis will observe the cylindricalradioactive emission source 115 as a circle 115, adding new informationto the views along the x and y axes.

As FIGS. 3A-3D illustrate, at times, views along two axes may beinsufficient for a three-dimensional definition of an object, and it maybe beneficial to include views with a component along the third axis.For the sake of definition, views along two axes will be referred tostereo views, while views that include a component of the third axiswill be referred to as cross views, since they intersect the planerstereo views.

Reference is further made to FIGS. 4A-4F, which schematically illustratestereo views and cross views, in accordance with embodiments of thepresent invention.

FIG. 4A illustrate the body 100 with a single assembly 20 arranged forviewing, for example, the heart 110. The assembly 20 is afforded withassembly oscillatory sweeping motion along the z-axis, as described bythe arrow 60, and preferably first and second preferably orthogonaloscillatory lateral motions, described the arrows 80 and 90,respectively.

As seen in FIG. 4B, the assembly oscillatory sweeping motion along thez-axis, described by the arrow 60, produces views 65 in the x-y planes.The first and second orthogonal oscillatory lateral motions, describedthe arrows 80 and 90, augment these with additional views 65 in the x-yplanes. The purpose of the first and second oscillatory lateral motionsis to compensate for “dead areas,” that is, structural areas and otherareas that do not participate in the detection, within the assembly 20and between the assemblies 20, so as to provide complete coverage of thebody 100, by the array 25 (FIG. 1A). These motions produce viewssubstantially in the x-y plane. It will be appreciated that there is acomponent of viewing in a third axis, due to the solid collection angleof the collimator 16. Yet this component is rather small.

Returning to FIG. 4A, the blocks 18 of the assembly 20 may be furtherafforded with block oscillatory sweeping motion, described by the arrow70 and preferably orthogonal to the assembly oscillatory sweeping motiondescribed by the arrow 60.

As seen in FIG. 4C, the block oscillatory sweeping motion, described bythe arrow 70, produces cross views 75, which supplement views 65, byproviding components of the third axis, namely, the z-axis. Asillustrated in FIGS. 3A-3D, hereinabove, the views 75 may add additionalinformation, not available or barely available in the views 65 along thex-y planes.

FIGS. 4D and 4F illustrate an alternative mode for acquiring the crossviews 75. Accordingly, the dynamic camera 10 further includes assemblies22, arranged at an angle β to the assemblies 20, and moving with anassembly oscillatory sweeping motion, described by an arrow 62, so as toprovide the cross views 75.

It should be noted that the detectors of the dynamic camera 10 do nothave to be arranged in arrays. In one embodiment of the presentinvention the detectors are scattered in front of the body so as toprovide complete coverage of the body internal overall volume. Thedetectors can be scattered in a certain structure or in an arbitraryorder.

The Position Tracker 50

The position tracker 50 is configured for providing information on theposition and orientation of each detecting unit 12, with respect to theoverall structure 15, substantially at all times, during the individualassembly motion.

In accordance with a preferred embodiment of the present invention, theposition tracker 50 relates to software and (or) hardware that receiveinformation from the motion provider 40 and calculate the position andorientation of each detecting unit 12, based on that information.Preferably, the calculation is performed within the control unit 55.

Alternatively, position sensors, as known, may be used for determiningthe position and angular orientation of each detecting unit 12.

Alternatively still, a combination of information from the motionprovider 40 and position sensors may be employed.

The Timing Mechanism 30

The timing mechanism 30 associates timing information with theradioactive emission data impinging the single-pixel detectors 14 of thedetecting units 12. Preferably, the timing mechanism 30 includes asingle clock used for all of the single-pixel detectors 14 in thedynamic SPECT camera 10, so that timing information is synchronized forthe camera as a whole. The timing information is collected at thesingle-pixel level, so that time binning may be performed for theemission data collected by each pixel. Exemplary methods for associatingtiming information with the radioactive emission data include:

1) Time stamping—Each event, impinging on a given single-pixel detector14 at a given time is stamped with a time of detection and a pixelidentification. Stamping may be performed by any manner known in theart, for example as a data packet header or footer. The time-stamped,pixel stamped radioactive emission data may be binned, per time and perpixel, by the control unit 55.

2) Time binning—In an alternate approach, timing information is providedfor a cumulative count collected from each single-pixel detector 14 overa fixed time interval, for example, 0.001 seconds, 1 second, or 10seconds, rather than for individual events. Each time bin is thenstamped with a time stamp or sequential number and pixel identification.One technique for performing time binning is to insert a periodic clockpulse into the data stream. The interval between the clock pulses equalsthe minimum bin length. Thus, periodic pulses every 0.001 seconds maylead to bin lengths of 0.001 seconds or greater, for example, 1 second,or 10 seconds.

The timing Mechanism 30 is used by the reconstruction module in order toallow the separate reconstruction of the dynamic and static volumetricregions. The timing Mechanism 30 allows the reconstruction module toapply a time binning with a certain length on the dynamic volumetricregion and a time binning with another length on the static volumetricregion.

Time Scale Considerations

Dynamic studies, aimed at obtaining kinetic parameters, require theacquisition of full-reconstructed images at a rate that is no greaterthan about half the frequency of the sampled kinetic parameter. Forexample, for adult humans, blood circulates through the body at a rateof about 1 cycle per minute. Thus, sampling a process affected by bloodcirculation should take place at a rate of at least two samplings perminute. Preferably, sampling should be at a much greater rate, forexample, 6 samplings or 10 samplings per minute—that is, about every 10seconds or about every 6 seconds.

Additionally, based on FIGS. 5A and 5B, according to Garcia et al. (Am.J. Cardiol. 51st Annual Scientific Session, 2002), showing physiologicalbehavior of different radiopharmaceuticals, dynamic studies for Tc-99mteboroxime are best performed within about the first 100 seconds afteradministration, and better still, within the first 60 seconds afteradministration.

Moreover, based on FIGS. 5A and 5B, the dynamic behavior of aradiopharmaceutical in the body, varies as a function of time, dependingon the radiopharmaceutical and on the time elapsed since itsadministration. For example, myocardial perfusion of Tc-99m teboroximeshows a very steep uptake between about the first 10-15 seconds and thefirst 50-60 seconds, followed by a more gradual washout, after the first60 seconds. The rate of sampling of Tc-99m teboroxime, during the first60 seconds after administration should be adjusted to the very steepuptake, for example, a sampling rate of every second. Forradiopharmaceutical with a slower dynamic behavior, a slower rate may besufficient.

It will be appreciated that a dynamic analysis requires preciseknowledge of the time of administration.

Obtaining the Time of Administration of a Radiopharmaceutical

As noted hereinabove, precise knowledge of the time of administration ofa radiopharmaceutical is important both in order to evaluatephysiological processes made visible by the radiopharmaceutical, withrespect to the time of the radiopharmaceutical's entry to the body andin order to perform the evaluation at an optimal period, with respect tothe radiopharmaceutical's cycle in the body.

There are several methods for acquiring precise knowledge of the time ofadministration of the radiopharmaceutical, as follows:

1. providing communication means between an administration device, forexample, a syringe or an IV device, and the dynamic SPECT camera 10, andcommunicating the precise time of administration, vis-a-vis a clock, bythe administration device to the dynamic SPECT camera 10. This methodmay be employed for example, when administration takes place when thepatient is positioned at the dynamic SPECT camera 10, for imaging.

2. providing communication means between the administration device, thedynamic SPECT camera 10, and a third unit, for example, a control systemor a hospitals ERP system, communicating the precise time ofadministration, vis a vis a clock, by the administration device to thethird unit, and reporting the precise time of administration by thethird unit to the dynamic SPECT camera 10. This method may be employedfor example, when administration takes place at a different locationthan the imaging station.

3. allowing the dynamic SPECT camera 10 to image the site ofadministration, for example, the arm of the patient, whileadministration takes place, while employing the timing mechanism 30 ofthe dynamic SPECT camera 10. A marker, for example, a line ofradioactive ink may drawn, for example, on the patient's arm or on theadministration device, for defining the time of administration as thetime the radiopharmaceutical first crosses the marker. Alternatively,observing a flow of the radiopharmaceutical in the administration deviceor in the patient's vein may be used to determine the time ofadministration.

4. Observing a transparent administration device, for example, with avideo camera, associated with a clock, may be employed for defining atime of administration based on the radiopharmaceutical distribution inthe administration device, or based on the time the radiopharmaceuticalfirst crosses a marker, visible by the video camera. Communicationbetween the video camera and the dynamic SPECT camera 10, or between thevideo camera, the dynamic SPECT camera 10, and a third unit will providethe information to the dynamic SPECT camera 10.

In accordance with embodiments of the present invention, theadministration may include various administration profiles, for example,bolus, continuous drip, or sinusoidal.

Spatial and Temporal Resolution

In order to meet the time scale considerations, described hereinabove,the dynamic SPECT camera 10 according to embodiments of the presentinvention is designed at least for acquiring a tomographicreconstruction image of about 15×15×15 cubic centimeters, which isapproximately the volumetric region of a heart, at a predeterminedspatial resolution of at least 10×10×10 cubic millimeters, at anacquisition time no greater than about 30 seconds. Preferably, theacquisition time is no greater than about 10 seconds, and morepreferably, the acquisition time is no greater than about 1 second.

Additionally, the spatial resolution of the tomographic reconstructionimage may be at least 7×7×7 cubic millimeters, or better yet, at least4×4×4 cubic millimeters, or better still, at least 1×1×1 cubicmillimeters.

Anatomically Varying Time-Bin Lengths

As discussed in the background section, the time binning is needed inorder to generate a clear imaging of a dynamic organ, such as the heart,or a section thereof. Though the time binning allows the acquisition ofa clear image of the heart, it has at least one major disadvantage. Thereconstruction of the image using time binning requires highcomputational throughput. Thus, binning images of the input overallvolume may provide a clear imaging of the heart however have highcomputational throughput. Reconstruction using anatomically varyingtime-bin lengths can be used to reduce to computational throughput ofthe time binning.

While some body organs, such as the kidney, the lung, or the liver, arerelatively static, so as to enable imaging of a period of time thatallows acquiring a statistically significant number of counts, the heartmoves relatively rapidly, with about 80-100 beats per minute, on theaverage. In one embodiment of the present invention, as the staticregion does not have to be gated to provide a clear imaging, only thedynamic region that preferably contains the heart is gated. In such anembodiment, fewer voxels are gated and therefore the computationalcomplexity is reduced.

In such an embodiment, different areas in the body can be gated in arate that is adjusted to according to a respective level of activeness.For example, the heart that has high level of activeness can be gatedusing a large number of bins, the visceral background, which isrelativity static, is gated using one of two bins, and the stomach, thathave higher level of activeness than the visceral background but lowerlevel of activeness than the heart is gated using a limited number ofbins.

As described below, performing gated image reconstruction usinganatomically varying time-bin lengths improves the reconstructionquality, reduces the reconstruction time, or both. The improvement is anoutcome of a reduction in the needed computational resources.

Reference is now made to FIGS. 15 and 16, which are respectively aschematic isometric view of the input overall volume 1001 segmented intodynamic volumetric region and static volumetric regions 1003, 1002, asdepicted in FIG. 14, and a schematic cross-sectional view of thesegmented input overall volume 1001A taken along the lines Ill-Ill,according to one embodiment of the present invention.

As described below a radioactive emission image of the input overallvolume 1001 is segmented into a non-gated region, which includesnon-gated voxels, in accordance with the static volumetric region 1002,and to a gated region, which includes gated voxels, in accordance withthe dynamic volumetric region 1003. Preferably, the dynamic volumetricregion 1003 is adjusted to delimit a dynamic organ, such as the humanheart that is schematically represented by a hollow sphere 1004.Preferably, the dynamic volumetric region 1003 is larger than theapparent volumetric region of the heart 1004 to account for segmentationerrors. It should be noted that the dynamic volumetric region 1003 maybe adjusted to contain other human and animal internal organs such asthe stomach. In FIG. 16, the hatched region 1003A represents thecross-section of the dynamic volumetric region 1003 and the annularcrosshatched region 1004A schematically represents a cross-sectionthrough the heart muscle of the heart 1004. The region 1002A representsa cross section of the static volumetric region 1002.

It should be noted that the cubical shape of the dynamic volumetricregion 1003 and the static volumetric region 1002 are not obligatory andthe segmentation to regions may be performed using differently shapedvolumetric regions. Preferably, the dynamic and the static volumetricregions 1003, 1002 have several non-connected parts. For example, thedynamic volumetric region 1003 may be a spherical volumetric region, anellipsoid of revolution, an ellipsoid with a hole that represents theblood inside the heart, a cylindrical volumetric region or any othertype of suitable regularly shaped or non-regularly shaped volumetricregion. Preferably, the dynamic volumetric region 1003 comprisesnon-connected components, which may be referred to as sub-volumetricregions.

Reference is now made jointly to FIG. 15, previously described, and toFIG. 17, which is a flowchart that depicts a method for reconstructionan input overall volume using anatomically varying time-bin lengths,according to one embodiment of the present invention.

During the first step, as shown at 1301, radiation emitted from theinput overall volume 1001 is captured by the SPECT detectors andrecorded, as described above. The captured radiation is used to generatea set of gated images, which are used to overcome distortions such asmotion artifacts. As described above, each gated image is generated by aphoton counting that takes into account the portion of the heartcontraction cycle within which a photon is measured. The number ofphotons hitting the detector within a specific integration time iscalculated and used as raw data, which may be referred to as datasets.

Then, as shown at step 1302, the captured datasets are firstly used inan initial reconstruction process in which an initial estimation imageis generated. Preferably, a non-gated reconstruction is used to providea reconstruction that estimates the static intensity distribution.

In the following step, as shown at step 1303, the initial estimationimage is segmented to a gated region and a non-gated region thatrespectively define the boundaries of the dynamic and static volumetricregions.

The segmentation of the input overall volume 1001 to dynamic and staticvolumetric regions 1003, 1002 is performed using a suitable imagesegmentation method or process.

Preferably, the input overall volume 1001 is further segmented to one ormore other segments such as the liver. Such segments may be joined tothe dynamic or to the static volumetric regions 1003, 1002 according tothe nature of the activity level of the segment. For instance, the livermay be joined to the static volumetric region.

The segmentation to static and dynamic volumetric regions may beperformed using a number of possible methods. In one embodiment of thepresent invention, a system user marks the boundaries of the dynamicvolumetric region that comprises the gated voxels. In such anembodiment, the reconstructed image is displayed on a screen of a userinterface that allows the system user to delimit the dynamic volumetricregion. Though the captured image is blurry, as it is not gated, itprovides the system user a perceptual image of the outlines of theinternal organs in the input overall volume, including the heart, theliver, the spleen, the kidneys, and the aorta. In such an embodiment,the system user segments the captured image to gated and non-gatedregions according to their level of activity, thereby defines the gatedand non-gated regions. Preferably, the system user segments the heart asa non-gated region.

In one embodiment of the present invention, the segmentation is based ona voxel value threshold that reflects a certain percentage of themaximal reconstruction value. In such an embodiment, voxels of thereconstructed image having a value above the threshold are presumed tobe voxels that depicts the heart and tagged as gated voxels of thedynamic volumetric region and voxels of the input overall volume 1001having a value below the threshold are tagged as non-gated voxels of thestatic volumetric region. Preferably, regions in the captured image aresegmented according to predefined characteristics. For example, theliver region, which can be characterized as a very large segmentresiding in the lower part of an image that depicts the thorax, isidentified and segmented as a static volumetric region 1003 or a sectionthereof.

Preferably, the predefined threshold is defined according to theradiation intensity of the visceral background of the input overallvolume 1001. In such an embodiment, the radiation intensity of thevisceral background is estimated before the segmentation process. Suchan initial estimation can be performed using median or linear filterssuch as Gaussian and moving average filters. Each one of the voxels ofthe input overall volume 1001 with a value that is well above theestimated background radiation is tagged as a gated voxel. Each one ofthe voxels of the input overall volume 1001 with a value, which is belowthe estimated background radiation, is tagged as a non-gated voxel.

In one embodiment of the present invention, the segmentation isperformed according to morphological segmentation methods that adjustedaccording to the volumetric characteristics of the segmented volumetricregions. For example, for the heart that has convex faces can besegmented using top hat transform.

In one embodiment of the present invention, the segmentation isperformed according to the growing rate of regions of the input overallvolume 1001. In such a manner, regions such as the heart may beindented. In one embodiment, voxels having high growing rate areclustered as a group of voxels that depicts the heart.

In one embodiment of the present invention, the faces of the heart areidentified. Such identification may be performed using an objectivefunction with two parts. One part of the objective function is dependenton the organ border smoothness alone and the other part is dependent onthe edge strength near a defined border, see M. Kass, A. Witkin, and D.Terzopoulos. Snakes: active contour models, International Conference onComputer Vision, pages 259-268, 1987, which is incorporated in itsentirety by reference into the specification.

For clarity, Z_(dyn)(u) and Z_(stat)(u) respectively denotes the dynamicvolumetric region and the static volumetric region of the capturedimage. The dynamic and static volumetric regions respectively define theboundaries of gated and non-gated regions in the radioactive emissionimage that depicts the input overall volume. It should be noted thatthough only two volumetric regions are exemplified hereinbelow, theoverall volume may be segmented according to any number of volumetricregions such as three volumetric region, four volumetric region, tenvolumetric region etc.

Preferably, after the gated and non-gated regions of the radioactiveemission image have been segmented according to the dynamic and staticvolumetric regions, different resolutions are used for gated andnon-gated voxels. In such an embodiment, the computational load of thereconstruction may be reduced by using large voxels with a lowresolution in the static volumetric region 1002 and small voxels in thegated volumetric region.

Preferably, various morphological methods, such as, dilation, closingand the like are used after the initial segmentation to expand thedynamic volumetric region 1003. The broadening of the dynamic volumetricregion 1003 is done in order ensure that if the segmentation has beenmade according to an organ in a contracted state, the dynamic volumetricregion 1003 still encompasses the organ in an expanded state.

After the static and dynamic volumetric regions have been segmentedduring the initial reconstruction process, time binning of the dynamicvolumetric region of the input overall volume is performed and aseparate reconstruction of the static and the dynamic volumetric regionsis enabled. As shown at 1304-1306, the reconstruction is based on aniterative process in which the time binning of gated images of thedynamic volumetric region is enabled.

For clarity, I₀(u) denotes an input image I, which is preferablyconstant, that depicts u∈U voxels, t denotes a certain detector, gdenotes a certain gate in a set of G gates, such as 8, 16, and 24,ϕ_(t)(u) denotes a standard functional matrix that depicts the detectionprobability of a photon emitted from location u∈U to be detected bydetector t, s_(t) denotes the sensitivity of the detector t, T_(t) ^(g)denotes the integration time of detector t for gate g, I^(g)(u) denotesa set of G gated reconstructed images, y_(t) ^(g) denotes the number ofphotons that are emitted from voxel u and detected in detector t at gateg.

T_(t) denotes the integration time of detector t and calculated asfollows:T _(t)=Σ_(g) T _(t) ^(g)

I_(stat)(u) and I_(dyn) ^(g)(u) respectively denote static and dynamicregion images, where I_(stat)(u) and I_(dyn) ^(g)(u) are mutuallyexclusive as I_(stat)(u)·I_(dyn) ^(g)(u)=0, ∀u.

Z_(dyn)(u) and Z_(stat)(u) respectively denote static and dynamicregions in I, as defined in the aforementioned segmentation process.Preferably, Z_(dyn)(u) and Z_(stat)(u) are defined as follows:

${Z_{dyn}(u)} = \left\{ {{\begin{matrix}{1,} & {u \in \;{{dynamic}\mspace{14mu}{region}}} \\{0,} & {otherwise}\end{matrix}{Z_{stat}(u)}} = {1 - {Z_{dyn}(u)}}} \right.$

Preferably, before the input overall volume I is iterativelyreconstructed, few preliminary sub-steps are taken. During the firstsub-step, stat I_(stat)(u) and I_(dyn) ^(g)(u) are initialized asfollows:I _(stat)(u)=I ₀(u)·(1−Z _(dyn)(u))I _(dyn) ^(g)(u)=I ₀(u)·Z _(dyn)

Preferably, if Z_(dyn)(u)=0, the size of I_(dyn) ^(g)(u) is reduced.

As described above, Z_(dyn)(u) and Z_(stat)(u), which respectivelyconfine the static and dynamic volumetric regions, are defined at step1302.

During the second sub-step the scale is calculated as follows:

scale_(O.S.) ^(g)(u)=Σ_(t∈O.S.) S _(t) ·T _(t) ^(g)·ϕ_(t)(u)scale_(O.S.)(u)=Σ_(g)scale_(O.S.) ^(g)(u)After the preliminary steps have been completed, the reconstruction ofthe input overall volume according to time binning process commences.Preferably, during the reconstruction I_(stat)(u) and I_(dyn) ^(g)(u)are calculated for each voxel u∈U in the input overall volume.

During each iteration of the time binning process, as shown at 1305, thegated and non-gated regions that represent the static and dynamic imagesI_(stat)(u), I_(dyn) ^(g)(u) are updated. The updating of the regions iscalculated according to a deviation between the number of photons thathas been detected by the SPECT detectors and an estimation of thisnumber, as described below. During each one of the iterations, the gatedvoxels of the dynamic volumetric region are binned according to thenumber of gates and the non-gated voxels are binned only once. As thenon-gated voxels are binned only once, the computational complexity ofthe process is relatively low. The separation between the static anddynamic volumetric regions improves the computational efficiency andreduces the statistical variance.

In particular, in order to calculate I_(stat)(u) and I_(dyn) ^(g)(u), anumber of sub-iterations take places. First, ŷ_(stat,t) is calculated asfollows:ŷ _(stat,t) =s _(t) T ^(t)Σ_(u)ϕ_(t)(u)I _(stat)(u)

Where ŷ_(stat,t) denotes an estimation of the number of photons that areemitted from the voxels u∈U and detected by detector t, wherein valuesof voxels from the dynamic volumetric region are zeroed. It should benoted that the sensitivity parameter of and the integration time ofdetector t are taken into account at some stage in the calculation.

Then, ŷ_(dyn,t) ^(g) is calculated as follows:ŷ _(dyn,t) ^(g) =s _(t) T _(t) ^(g)Σ_(u)ϕ_(t)(u)I _(dyn) ^(g)(u)

Where ŷ_(dyn,t) ^(g) denotes an estimation of the number of photons thatare emitted at gate g from voxels u∈U and detected in detector t,wherein values of voxels from the static volumetric region are zeroed.It should be noted that the sensitivity parameter and the integrationtime of detector t for gate g are taken into account at some stage inthe calculation.

ŷ_(t) ^(g) is calculated according to ŷ_(dyn,t) ^(g) and ŷ_(stat,t), asfollows:ŷ _(t) ^(g) =ŷ _(stat,t) +ŷ _(dyn,t) ^(g)

Where ŷ_(t) ^(g) denotes an estimation of the number of photons that areemitted from a certain voxel u∈U and detected by detector t at gate g.It should be noted that unlike the calculation of y_(t) ^(g), thecalculation of ŷ_(t) ^(g) does not take into account the integrationtime and the sensitivity factor.

Then, for each gate g, the numerator num^(g)(u) is evaluated as follows:

${{num}^{g}(u)} = {\sum\limits_{t}{\frac{y_{t}^{g}}{{\hat{y}}_{t}^{g}}\left( {{s_{t}T_{t}^{g}{\phi_{t}(u)}} - 1} \right)}}$

Where num^(g)(u) sums the deviation between the number of photons thatare emitted from voxel u and detected in detector t at gate g and theestimation thereof of all the detectors, wherein the sensitivity and theintegration time of each detector t are taken into account. It should benoted that the calculation can be directly extended to an ordered setsmethod or any of its variations by summing the deviation over subsets ofthe group of detectors.

Based thereupon, the numerator num(u) is evaluated as follows:num(u)=Σ_(g)num^(g)(u)

Where num(u) is a sum of all the numerators that are evaluated for everyg∈G.

I_(stat)(u) and I_(dyn) ^(g)(u) are updated according to the calculationof the aforementioned scales and numerators, as follows:

$\begin{matrix}{{{I_{stat}(u)} = {{I_{stat}(u)} + {\frac{{num}(u)}{{scale}(u)} \cdot {I_{stat}(u)}}}}{{I_{{dy}\; n}^{g}(u)} = {{I_{dyn}^{g}(u)} + {\frac{{num}^{g}(u)}{{scale}^{g}(u)} \cdot {I_{{dy}\; n}^{g}(u)}}}}} & \;\end{matrix}$

The updated I_(stat)(u) and I_(dyn) ^(g)(u) are stored and used duringthe next iteration, as shown at step 1306. Steps 1303-1306 are repeatediteratively until the reconstruction of the input overall volume hasreached a desired quality.

Preferably, in order to determine whether the reconstruction has reacheda desired quality, as shown at 1306, the number of gated voxels withactivity above a predefined threshold is checked. For example, thenumber of gated voxels with activity level that is in the range betweenthe maximal gated voxel intensity value and 20% therefrom is checked.

When the time binning process has been completed, as shown at 1306, agated reconstructed image can be generated as follows:I ^(g)(u)=I _(stat)(u)+I _(dyn) ^(g)(u)

Reference is now made to FIG. 18, which is a graphical representation ofone dimensional vector I_(c) of voxels that represents thereconstruction of the input overall volume. Preferably, all thenon-gated voxels I_(stat)(u) that represent static regions of the inputoverall volume U are arranged 1101 first within the vector I_(c). Thenon-gated voxels are followed 1101 by gated voxels that comprise a setof different frames in a consecutive order that are arranged inclusters. Each cluster represents the dynamic volumetric region of theinput overall volume at a certain frame. The frames are denoted by1102A, . . . , 1102G. The frames can be arranged in any predefinedorder.

As described above, ϕ_(t)(u) is a standard functional matrix thatdepicts the detection probability of a photon emitted from a voxel u∈Uto be detected by a detector t. Since ϕ_(t)(u) is a sparse matrix, thenumber of math operations can be reduced by defining ϕ_(t) ^(g)(u) whichis zero wherever I_(dyn) ^(g)(u) is zero.

Reference is now made jointly to FIG. 15, previously described, and toFIG. 19, which is a flowchart that depicts another method forreconstruction an input overall volume using anatomically varyingtime-bin lengths, according to another embodiment of the presentinvention. In the method depicted in FIG. 19, the static region isestimated only once according to the initial reconstruction processstep.

The method depicted in FIG. 19 is based on the assumption that thenon-gated static region equals to the average of the gated dynamicregion images reconstructions. Though the assumption is not accurate, itis expected to be sufficient for the reconstruction of the input overallvolume. As the static region is calculated only once, the memory usageand the computational complexity decrease.

Steps 1301 and 1302 are as depicted in FIG. 17. During steps 1301 and1302 the first step I(u) is obtained. Then, as shown at 1310 and 1311,I(u) is segmented to current and static regions, preferably according tothe following equations:I _(stat)(u)=I(u)·(1−Z _(dyn)(u))I _(dyn) ^(g)(u)=I(u)·Z _(dyn)(u), for each g∈G

In order to reduce the computational complexity of the followingiterative process, ŷ_(stat,t) is evaluated in advance as follows:ŷ _(stat,t) =s _(t) T ^(t)Σ_(u)ϕ_(t)(u)I _(stat)(u)

The previously described method uses the standard functional matrixϕ_(t)(u) that is a representation of the probability to detect a photonemitted from location u∈U by a detector t. The calculation of ϕ_(t)(u)requires high computational complexity as all the voxels of the inputoverall volume have to be calculated. In order to reduce thecomputational complexity a standard functional matrix that is limited todynamic voxels is used ϕ_(t,dyn)(u). The limited standard functionalmatrix is defined as follows:

${\phi_{t,{{dy}\; n}}(u)} = \left\{ \begin{matrix}{{\phi_{t}(u)},} & {{u\; \in {{dynamic}\mspace{14mu}{region}}}\mspace{281mu}} \\{0,} & {otherwise}\end{matrix} \right.$

Then, for each g∈G, the scale on the dynamic region scale^(g)(u) isevaluated, as described above.

During the following step, as shown at 1312, the dynamic volumetricregion I_(dyn) ^(g)(u) is calculated. In particular, in order tocalculate I_(dyn) ^(g)(u), a number of sub-iterations take place. First,I_(dyn) ^(g)(u) is calculated using ϕ_(t,dyn)(u) as follows:ŷ _(dyn,t) ^(g) =s _(t) T _(t) ^(g)Σ_(u)ϕ_(t)(u)I _(dyn) ^(g)(u)

Then based on ŷ_(dyn,t) ^(g) and ŷ_(stat,t) that has been calculated inthe step 1310, ŷ_(t) ^(g) is calculated as follows:ŷ _(t) ^(g) =ŷ _(stat,t) +ŷ _(dyn,t) ^(g)

Where ŷ_(t) ^(g) denotes an estimation of the number of photons that areemitted from a certain voxel u∈U and detected by detector t at gate g.It should be noted that unlike ŷ_(dyn,t) ^(g), ŷ_(stat,t) is notrecalculated during the iterative process.

Then, for each gate g, the numerator num^(g)(u) is evaluated as follows:

${{num}^{g}(u)} = {\sum\limits_{t}{\frac{y_{t}^{g}}{{\hat{y}}_{t}^{g}}\left( {{s_{t}T_{t}^{g}{\phi_{t}(u)}} - 1} \right)}}$

Based on the calculation of the scale that has been calculated beforethe iterative process and the numerator that is calculated according toradiation emitted from the dynamic region and captured by the detectors,I_(dyn) ^(g)(u) is updated as follows:

${I_{{dy}\; n}^{g}(u)} = {{I_{d\;{yn}}^{g}(u)} + {\frac{{num}^{g}(u)}{{scale}^{g}(u)} \cdot {I_{d\;{yn}}^{g}(u)}}}$

The updated I_(dyn) ^(g)(u) is stored and used during the nextiteration, as shown at step 1316.

Then, as shown at 1313, the input overall volume is reconstructed usingthe updated dynamic region and the static region. As shown at 1314,steps 1311-1314 are repeated iteratively until the reconstruction of theinput overall volume has reached a desired quality. In the end of eachon of the iterations, the dynamic region is updated, as described above.

When the iterative process has been completed, as shown at 1314, a gatedreconstructed image can be generated as follows:I ^(g)(u)=I _(stat)(u)+I _(dyn) ^(g)(u)

The gated voxels in the dynamic volumetric region 1003 may representischemic regions of the heart. The radiation reflected from suchischemic regions may have specific radiation patterns such as a centerwith low radiation. Thus, such regions can be reconstructed usingmorphological closing methods or by taking into account the typicalshape of the heart (one way is by fitting an ellipsoid to the edges inthe image, but other methods may also be used).

Reference is now made to FIG. 20, which is a graphical representation ofa position of two selected sub-regions in two sequential frames. Asdescribed above, the reconstruction of the dynamic volumetric region isbased on time binning of a number of consecutive frames that depict adynamic organ such as the heart. As each frame is based on a number ofgated images, it has high computational load.

In one embodiment of the present invention, the set of frames is a setof sequential images that depict the heart. As all the frames depict thesame input overall volume and as the heart has an expected movementpattern, we can use one or more frames to estimate another. In such amanner, fewer frames are calculated and therefore the computationalcomplexity of the reconstruction decreases. Preferably, during the timebinning, geometrical information from one or more prior frames assist inthe reconstruction of subsequent one or more frames. Such geometricprior methods are generally well known and therefore, are not describedhere in greater detail.

For example, FIG. 20 depicts two sequential frames, frame i−1 1054 andframe i 1056, which are taken from a sequence of M frames. Thesub-regions 1057A and 1059A in frame 54 schematically represent twodifferent regions of the heart 1055. The regions 1057B and 1059B offrame 1056 schematically represent the respective positions of regions1057A and 1059A in frame 1056. The change in the positions is an outcomeof the movement of the heart 1055. The vector T1 represents the movementof the region 1057B relative to the region 1057A and the vector T2represents the movement of the region 1059B relative to the region1059A. T1 and T2 can be used to estimate the position of additional oneor more frames in some of the embodiments of the present invention. See,Green P, Bayesian Reconstructions from Emission Tomography Data using aModified EM Algorithm, IEEE Tran. On medical imaging vol. 9 No. 1, March1990, pp. 84-93 and Fessler J, 2004 NSS/MIC statistical imagereconstruction short course notes entitled “Statistical Methods ForImage Reconstruction”,www(dot)eecs(dot)umich(dot)edu/fessler/papers/files/talkIO4/mic(dot)notes(dot)Pdfwhich are incorporated in their entirety by reference into thespecification. Preferably, voxels that represent the same anatomicallocation are stated to be alike. Therefore, voxels from different framesthat represent the same anatomical location can form a clique, or aneighborhood, as defined by the Gibbs prior equation. The strength ofapplying such a geometric prior may be depended on the movementamplitude and on the gate phase.

Dynamically Varying Time-Bin Lengths

There are times when dynamically varying time-bin lengths are desired.For example, Tc-99m-teboroxime has an uptake curve (FIG. 5B) which isvery steep during the uptake and which becomes less so during thewashout. Thus, different time-bin lengths may be desired for differentportions of the Tc-99m-teboroxime uptake curve. Similarly, differentradiopharmaceuticals have different uptake curves, and dedicatedtime-bin lengths may be desired for each radiopharmaceutical, and fordifferent portions of their respective uptake curves. Moreover, thecardiac RR cycle has very steep periods, during the rise and fall of theR peak (FIG. 5F), followed by periods that are nearly flat as a functionof time. Again, time bin lengths of different durations may be employedfor the different portions of the RR cycle. Furthermore, while theactual region of interest, for example, the heart, requires imaging at avery high level of accuracy, adjacent regions, for example, the chestmuscle, may be of lesser interest, and may be viewed at time bins ofgreater lengths. Additionally, continuous acquisition mode may requireshorter time-bin lengths than stop and shoot mode.

For example, the actual rise and fall of the R peak may be gated at timebins of 10 milliseconds, while the nearly leveled U-wave may be gated at100 milliseconds. Similarly, while the heart muscle may be gated at anaverage time bin of 50 milliseconds, the adjacent chest muscle may begated at time bins of 1 second and longer. It will be appreciated thatother values may similarly be employed.

In accordance with embodiments of the present invention, a lookup systemof recommended time-bin lengths may be provided, for specifyingrecommended time-bin lengths as functions of one or more of thefollowing:

a specific region of interest;

an administered radiopharmaceutical;

time elapsed since the administration of the radiopharmaceutical;

cardiac state with respect to an RR cycle;

a view of the detecting unit 12, with respect to the region of interest;

patient general data; and

data acquisition mode.

The lookup system may be, for example, tables or curves.

Thus the dynamic SPECT camera 10 may be configured for time binning atdynamically varying time-bin lengths, by providing communication betweenthe timing mechanism 30 and the lookup system, wherein the timingmechanism is configured for selecting a recommended time-bin length fromthe lookup system, for each time bin.

Clearly, if the input image has been segmented to gated and non-gatedregions, as described in above, only the gated region is gated at timebins at dynamically varying time-bin lengths.

Dynamically Varying Spectral Bins

It is sometimes of value to image only a specific spectral bin so as toeliminate scatter or contributions from other radiopharmaceuticals.Additionally, it may be of value to image several spectral binssimultaneously, for different radiopharmaceuticals, wherein differentgroups of detecting units are dedicated to different spectral bins.

Thus, the dynamic SPECT camera 10 may be configured for dynamicallydetermining a spectral energy bin for each detecting unit 12, asfollows:

providing a spectral selection mechanism 56 (FIG. 1A), for enabling aselection of a spectral energy bin to be used for each detecting unit12, independently from the other detecting units 12; and

a lookup system of recommended spectral energy bin values, as functionsof at least one of a specific region of interest, an administeredradiopharmaceutical, time since the administration of theradiopharmaceutical, a view of the detecting unit with respect to theregion of interest, and patient's details;

wherein the spectral selection mechanism 56 is further configured fordynamically determining the spectral energy bin for each detecting unit,as functions of the specific region of interest, the administeredradiopharmaceutical, the time elapsed since the administration of theradiopharmaceutical, the view of the detecting unit with respect to theregion of interest, and patients' details, from the lookup system.

The spectral energy bin is designed to include a primary photon energy±10%, or the primary photon energy ±7%, or the primary photon energy±5%.

Additionally, at least two radiopharmaceuticals may be administered andviewed by different groups of detecting units, each group beingconfigured for a different spectral energy bin, so as to view eachradiopharmaceutical in the same region independently of the otherradiopharmaceutical.

The spectral selection mechanism may be a hardware unit or software.

The spectral selection may be performed during data acquisition, orlater.

Intracorporeal Dynamic SPECT Camera

Referring further to the drawings, FIGS. 6A-6I describe the dynamicSPECT camera 10 as an intracorporeal dynamic SPECT camera 10, whichincludes a single assembly 20, preferably configured for oscillatorysweeping motion around its longitudinal axis—the z axis, as described bythe arrow 60. The blocks 18 may be further configured for oscillatorysweeping motion in an orthogonal direction, as described by the arrows70. An end block 18′ may be further configured for motion, for example,as described by the arrow 70′. It will be appreciated that other motionsare similarly possible, for example, oscillatory lateral motions, orrotational motions. For example, the arrow 90 describes the oscillatorylateral motion along the z axis of the assembly 20.

An ultrasound transducer 45 may be included with the intracorporealdynamic SPECT camera 10.

Other features of the intracorporeal dynamic SPECT camera 10 are asdescribed for the dynamic SPECT camera 10 of FIGS. 1A-1D.

FIG. 6A illustrates the intracorporeal dynamic SPECT camera 10 as asingle rigid unit, for example, for rectal or vaginal insertion. FIG. 6Cillustrates the intracorporeal dynamic SPECT camera 10 as having anincorporeal portion 44, an extracorporeal portion 42 and a cable 46, forexample, for insertion to the esophagus.

FIGS. 6F and 6E illustrate motions of the blocks 18, as described by thearrows 70. FIGS. 6F-6I illustrate motion of the assembly 20, asdescribed by the arrow 60.

Reconstruction with Object Implantaion

As described above, the reconstruction of the radioactive emission imageis based on datasets that have been acquired from a certain overallvolume, such as the thorax, with objects having known volume andstructure, such as the heart. As the reconstructed volumetric region hasa known structure and comprises organs with estimated structure,relative location, and volume, the throughput of the reconstruction canbe reduced.

The reconstruction process is an iterative process. During each step,the reconstruction of the overall volume and one or more volumetricregions thereof are being refined. Preferably, one or more objectmodels, which are defined according to an image, such as a CT or an MRIimage, an anatomical atlas, or other accurate reconstructions ofrespective objects, are used to improve and enhance the reconstructionprocess.

Object implantation proceeds as follows: after a few iterations, whichprovide a general idea of both:

i. the location and general shape of an organ in question, such as aheart, lungs, a stomach, visceral background elements, etc.; and

ii. an estimation of the expected number of photons that are emittedfrom different portions of the organ in question,

the general shape and photon counts of the organ in question arereplaced by an implanted model, based on a CT image, an MRI image, ananatomical atlas, or the like, thereby providing both:

-   -   i. a better definition of edges between the organ in question        and the surroundings; and        ii. some analytical evaluation of the expected number of photons        that are emitted from different portions of the organ in        question, based on the first few iterations, for example, given        that the organ is a heart, an average count values for the blood        and for the heart muscle, respectively, may be used, based on        first few iterations, for the different areas of the model. It        will be appreciated that an anatomical construction of voxels        may be employed with the voxel implantation.

In this manner, object implantation improves the reconstruction that isbased on counting statistics.

It will be appreciated that object implantation may be employed once orseveral times during the reconstruction process, each time, providing abetter starting point for the next iteration.

Object implantation comes to solve the problem that during the firststeps of the reconstruction, a blurry radioactive emission image of theoverall volume is received, as described above. An organ, such as theheart, can be identified in the blurry radioactive emission imageaccording to a cluster of voxels with expected values in an expectedrelative position. The value of voxels in such a cluster can be adjustedor changed according to a respective object model. For example, if aftera certain number of iterations a cluster of voxels in the upper rightsection of the overall volume has voxels with a certain average expectedvalue, the cluster can be identified as the heart. As it is known thatthe number of photons, which are emitted from voxels of the heart isrelatively high, the value of voxels in the related cluster are adjustedor changed to have relatively high values, according to the objectmodel. In such a manner, the actual shape of the heart can bereconstructed more efficiently.

Reconstruction Using a Minimal Number of Gray Levels

Strictly speaking, variations in radioactive emission activity betweendifferent voxels can be infinite, one voxel showing a photon count of17,584/for a given time period, and another, a photon count of18,900/for the given time period. Yet, to a doctor, interested inidentifying background muscles, heart muscles, or blood, and further,interested in differentiating between healthy heart muscle, ischemicmuscle, and dead tissue, a few levels of gray, for example, between 5 or10 levels or gradations of gray, may be sufficient. Thus, reconstructionneed not be carried out in order to evaluate an accurate photon countper voxel, but merely to determine the level of gray, from amongst 5-10levels of gray, per voxel.

As described above, the reconstruction of the radioactive emission imageis based on datasets that have been acquired from a certain overallvolume. The reconstruction is performed by summing up the photons thatare emitted from voxels of the overall volume. The sums of the emittedphotons are translated to gray level values, which are used toreconstruct the radioactive emissions image. Preferably, in order todetermine whether the reconstruction has reached a desired quality, thenumber of voxels with activity above a predefined threshold is checked.For example, the number of voxels with activity level that is in therange between the maximal voxel intensity value and 20% therefrom ischecked. Other criteria may be determined is order to evaluate whetherthe reconstruction has reached a desired quality. Threshold values arepreferably chosen empirically to yield accurate reconstruction of theoverall volume. This analysis applies to gated and ungated regions,alike.

Preferably, the values of the voxels are mapped to a limited number ofgray level values, such as 5, 7, 8, 9, or 10. By limiting the number ofgray level values a radioactive emissions image, which is morecoarsened, is generated and the computational load of the reconstructionprocess is reduced. Though such a limitation reduces the sharpness andthe contrast level of radioactive emission image, the coarsenedradioactive emission image still depicts enough information that allowsa physician to identify ischemic regions in the overall volume. Itshould be noted that such a mapping may separately be used on one ormore volumetric regions of the overall volume, preferably according tothe dynamic characteristics thereof.

Image Acquisition Modes

In accordance with embodiments of the present invention, several imageacquisition modes are available, as follows:

In a continuous acquisition mode, also referred to as fanning, data isacquired while the array, the assembly, or the block is in continuousmotion. Continuous acquisition mode may apply also to oscillatorymotions, although strictly speaking there is a momentary pause with eachchange of direction. This mode leads to some blurring of the data, butit does not require the array, assembly, or block to stabilize betweenperiods of motion and periods of stationary data acquisition.

In a stop and shoot acquisition mode, incremental travels are followedby stationary acquisition intervals. This mode leads to betterresolution, yet it requires a damping period, to allow the array,assembly, or block to stabilize between periods of motion and periods ofstationary data acquisition, as discussed hereinbelow, under theheading, “Stability and Damping Time”.

Interlacing is a fast stop and shoot acquisition mode with oscillatorymotion, for example, sweeping oscillatory motion, wherein on rather thanstopping at each predetermined locations, with each sweep, the oddlocations are visited on a right sweep and the even locations arevisited on the left sweep, or vice vera, so that each sweeping directionstops at different locations.

Prescanning relates to a fast prescan of a subject undergoing diagnosis,to identify a region-of-interest, and thereafter collect higher qualitydata from the region-of-interest. A prescan according to the presentinvention may be performed by the dynamic SPECT camera 10, preferably,with interlacing, or in a continuous mode, or by any other imagingdevice, including, for example, ultrasound or MRI.

Stability and Damping Time

Stop and shoot acquisition mode involves discontinuities in motionbetween travel and shooting modes, and at the beginning of each shootingmode, the assemblies 20 must be allowed to stabilize till vibrations areless than about ±0.25 mm, so as not to interfere with the acquisition.

Prior art SPECT cameras must allow for a damping time of about 5seconds, but the dynamic SPECT camera 10, according to embodiments ofthe present invention reaches stability in about 1 second or less.

FIG. 7 schematically illustrate the assembly 20, according toembodiments of the present invention. The damping time for the assembly20 may be described as:Damping Time=C×[(1/12)M(T ² +W ²)+MX ₀ ²],wherein:

M is the mass of the assembly 20;

T is the thickness of the assembly 20;

W is the width of the assembly 20;

X₀ is the axis of rotation; and

C is a constant that depends on the braking force applied to theassembly 20.

The factor 1/12 is calculated assuming the assembly proximal end istangential to the sweeping path.

As the damping time equation illustrates, the damping time is highlydependent on both the axis of rotation X₀ and the mass of the assembly20.

In the present case, the axis of rotation is that of the sweeping motiondescribed by the arrow 60 (FIG. 1A), which is considerably shorter thanan axis of rotation around the body 100.

Similarly, the mass of a single assembly is far less than that of aconventional SPECT camera.

Possible values for the assembly 20, according to embodiments of thepresent invention may be:

Weight of the assembly 20≈1.5 kg.

Thickness of the assembly 20≈5 cm.

Width of the assembly 20≈7 cm.

As such, the assembly is designed with a damping time constant of under50 msec during which vibrations amplitude subsides to under 0.25 mm.

It will be appreciated that the present example applies to bothextracorporeal and intracorporeal dynamic cameras.

Stationary Dynamic SPECT Camera

It may be desired to perform imaging, especially prescanning with astationary camera, that is without motion, for the following reasons:

1. in continuous acquisition mode, the blurring produced by the motionis eliminated;

2. in stop and shoot acquisition mode, the time spent in motion isavoided, as are the vibrations, associated with the discontinuitiesbetween the motions and the stationary intervals.

In general, a stationary camera does not provide sufficient viewingpositions and detecting units, yet the camera may be specificallydesigned to provide those, to a desired level.

Preferably, the assemblies 20 are positioned at optimal positions priorto imaging, and imaging takes place while the camera is stationary.

Thus, in accordance with embodiments of the present invention, there isprovided a stationary dynamic SPECT camera 10, which is described hereinwith reference to FIGS. 1A-1D. The stationary dynamic SPECT camera 10comprises:

the overall structure 15, which defines proximal and distal ends withrespect to a body;

the first plurality of the assemblies 20, arranged on the overallstructure 15, forming an array 25 of the assemblies 20, each assembly 20comprising:

-   -   a second plurality of detecting units 12, each detecting unit 12        including:    -   a single-pixel detector 14, for detecting radioactive emissions;        and    -   a dedicated collimator 16, attached to the single-pixel        detector, at the proximal end thereof, for defining a solid        collection angle δ for the detecting unit; and    -   an assembly motion provider 40, configured for providing the        assembly 20 with individual assembly motion with respect to the        overall structure, prior to the acquisition of        radioactive-emission data;

a position-tracker 50, configured for providing information on theposition and orientation of each of the detecting units 12, with respectto the overall structure 15, during the individual motion,

the stationary dynamic SPECT camera 10 being configured for acquiring atomographic reconstruction image of a region of interest whilestationary, for the whole duration of the tomographic image acquisition.

Preferably, the region of interest is about 15×15 ×15 cubic centimeters,and the tomographic image may be acquired during an acquisition time of60 seconds, at a spatial resolution of at least 20×20×20 cubicmillimeter.

Additionally, the tomographic image may be acquired during anacquisition time of 30 seconds, at a spatial resolution of at least20×20×20 cubic millimeter.

Furthermore, the tomographic image may be acquired during an acquisitiontime of 60 seconds, at a spatial resolution of at least 10×10×10 cubicmillimeter.

Additionally, the tomographic image may be acquired during anacquisition time of 30 seconds, at a spatial resolution of at least10×10×10 cubic millimeter.

Preferably, the structure 15 conforms to the contours of the body 100,for acquisition with substantial contact or near contact with the body.

Additionally, the assemblies 20 in the array 25 are configured toprovide stereo views in a plane and cross views.

Anatomic Construction of Voxels

Anatomic construction of voxels avoids the smearing effect of a rigidvoxel grid construction, where different tissue types, for example,blood and muscle, appear in a same voxel. This is important especiallyfor perfusion studies, where the perfusion of blood into the tissue issought.

Reference is now made to FIGS. 8A and 8B, which schematically illustratea rigid voxel grid construction and an anatomic construction of voxels,respectively, in accordance with the present invention.

FIGS. 8A and 8B illustrate a heart 200, having atria 202 and 204,chambers 206 and 208, and a muscle 218.

As seen in FIG. 8A, a rigid voxel construction 202 causes smearing ofthe different tissue types. However, as seen in FIG. 8B, blood andmuscle tissues are anatomically divided into different voxels, allowingan accurate study of perfusion. The atria and chambers are divided intoan anatomic voxel system 222, or to an anatomic voxel system 224, whilethe muscle is divided into a relatively coarse voxel system 226, or to afiner voxel system 228, as desired. It will be appreciated that theanatomic voxels may vary in volumetric region. For example, sinceischemia is not relevant to the atria and chambers, they may be dividedinto coarse voxels, while the heart muscle may be divided into finevoxels.

As further seen in FIG. 8B, the rigid voxel construction 202 may stillapplied to the surrounding chest muscle.

It will be appreciated that parametric equations, such as F(1) and F(2)may be created and used in the construction of the anatomic constructionof the voxels.

The following describes methods for obtaining the anatomic constructionof voxels.

A first method for the anatomic construction of voxels includes:

providing a structural image of a region of interest, such as a heart;

constructing an anatomic system of voxels, for the region of interest,in which voxel boundaries are aligned with boundaries of structuralobjects of the region of interest, based on the structural image;

performing radioactive-emission imaging of the region of interest,utilizing the anatomic system of voxels; and

performing reconstruction of the radioactive-emission imaging, utilizingthe anatomic system of voxels.

Preferably, the structural image is provided by a structural imager,selected from the group consisting of 2-D ultrasound, 3-D ultrasound,planner x-rays, CT x-rays, and MRI.

Additionally, the structural imager is co-registered to aradioactive-emission imaging camera which performs theradioactive-emission imaging.

Moreover, attenuation correction of the radioactive-emission imaging maybe performed, based on the structural image.

Furthermore, the structural image and the radioactive-emission image,constructed with the anatomic voxels, may be displayed together.

Alternatively, the structural imager is not co-registered to aradioactive-emission imaging camera which performs theradioactive-emission imaging, and further including corrections formisregistration.

Alternatively still, the structural image is provided from a lookupsystem, which is preferably corrected for patient's details.

It will be appreciated that the anatomic construction of voxels may bebased on fitting the boundaries of the structural objects to parametricequations and utilizing the parametric equations in the constructing ofthe anatomic system of voxels.

Additionally, the anatomic system of voxels includes voxels of varyingvolumetric regions, depending on their anatomic position and relevance.

Furthermore, the method includes time binning of the radioactiveemissions to time periods not greater than substantially 30 seconds, ornot greater than substantially 10 seconds, or not greater thansubstantially 1 second.

Additionally, the anatomic system of voxels includes voxels of varyingvolumetric regions, depending on the relevance of their dynamicactivity.

An alternative method for the anatomic construction of voxels includes,relates to the use of the radioactive emission imaging itself for theanatomic reconstruction, as follows:

providing a first system of voxels for a region of interest;

obtaining radioactive-emission data from the region of interest;

performing a first reconstruction, based on the radioactive-emissiondata and the first system of voxels, to obtain a first image;

correcting the first system of voxels, by aligning voxel boundaries withobject boundaries, based on the first image; thus obtaining a secondsystem of voxels;

performing a second reconstruction, based on the radioactive-emissiondata and the second system of voxels, thus obtaining a second image.

Alternatively, a set of radioactive emission data is obtained, possiblywith a second injection, in order to concentrate the viewing on theanatomic voxels, as follows:

providing a first system of voxels for a region of interest;

obtaining a first set of radioactive-emission data from the region ofinterest;

performing a first reconstruction, based on the first set of theradioactive-emission data and the first system of voxels, to obtain afirst image;

correcting the first system of voxels, by aligning voxel boundaries withobject boundaries, based on the first image; thus obtaining a secondsystem of voxels, which is anatomically based;

obtaining a second set of radioactive-emission data from the region ofinterest, based on the second system of voxels, which is anatomicallybased; and

performing a second reconstruction, based on the second set of theradioactive-emission data and the second system of voxels, thusobtaining a second image.

Anatomic Modeling

Bull's Eye, or polar map, is a semi-automatic method for thequantification and evaluation of coronary artery disease from SPECTtomograms obtained by marking the myocardium with Tl-201 or MIBI-Tc-99.The polar map is computed from cross-sectional slices of the LeftVentricle (LV). For each slice, the center and a radius of search thatcontains the LV are determined and the LV is divided into radialsectors. The maximum count value of each sector is computed, generatinga profile. Profiles are plotted as concentric circle onto the map. Theresulting map is a compression of 3D information (LV perfusion) onto asingle 2D image.

Yet the bull's eye or polar map is reconstructed from a rigorousgeometry of voxels, for example, of 5×5×5 mm, or 4×4×4 mm, which cutsacross tissue types, thus providing smeared information.

A voxel division that is based on an anatomical structure would behighly preferred, as it would allow the measurements of processes withinand across anatomical features, substantially without the smearingeffect. For example, if specific voxels are used to define bloodregions, and others are used to define muscle regions, than diffusionacross boundary membranes and other processes may be evaluated,substantially without a smearing effect.

Anatomical model is based on voxels that follow anatomical structures,and may be shaped for example, as a sphere, a tube, or as a shellsegment, rather than as a the standard cube.

When combined with a camera of high resolution and sensitivity and withgated measurements, anatomic modeling would be clearly advantageous overstandard, rigorous modeling, especially for kinetic studies aremeaningful only with respect to specific tissue types.

In accordance with embodiments of the present invention, the polar mapmay be produced with a reduced number of amplitudes, or levels, forexample, 7 levels of severity, or 5 levels of severity, from healthy tosevere.

Kinetic Modeling

As part of the imaging and analysis processes, the camera may be able toproduce a time series of 2D or 3D images, showing reconstructedintensity in overall volume and its changes over time.

Likewise, it may be desirable not to reconstruct the entire volumetricregion but only limited segments of interest. In those segments,resolution of segment definition may be very important in order tominimize partial volumetric region effect, which results in a biasedestimate of the kinetic process.

In an exemplary embodiment, the analysis of the kinetic process may beafter reconstruction of the intensity in the entire volumetric region orin the selected segments has been done for a series of time points. Inthat case, each segment or location in overall volume (u) has a list ofintensity (I) values in time (t), and the list I(u,t) may be furtheranalyzed to fit parametric kinetic model.

Such a parametric kinetic model may be a variety of kinds, depending onthe modeling on the biological process. Examples of such models may befound in PCT/IL2005/001173.

In a simplistic example, the model may beI(u,t)=B(t)·(1−e ^(−k) ¹ ^((u)·t))·e ^(−k) ² ^((u)·t)where B(t) is a concentration in the blood, whether obtained fromimaging a segment which is pure blood (e.g. major blood vessel, orvolumetric region within the heart chamber), or may be known from othersources (by injection profile, other invasive or non invasivemeasurements from the blood, etc). k₁(u) is the time constantrepresenting a process of uptake into the tissue at segment u, and k₂(u)is the time constant representing a process of washout from the tissueat segment u.

There may be many other models, and for example the equation above maytake other forms such asI(u,t)=B(t)*F ₁(k ₁(u),τ)*F ₂(k ₂(u),τ)where * stands for either multiply operation or convolution in mostcases, and F₁ and F₂ represent processes. In an example, the effect ofsuch process on the intensity may be modeled in linear cases byconvolution of the intensity in the blood with an impulse response of alinear process F₁ (k_(i)(u), τ). Each of these may include one or moretime constants k_(i)(u), and the time profile is described as a functionof time τ. There may be one or more such processes F_(i), for example 1(e.g. uptake or decay only), 2 (e.g. simultaneous uptake and clearanceprocesses, 3 (e.g. combination with accumulation or metabolism), 4 ormore.

A process of fitting may be used between the reconstructed intensity inoverall volume and time and the parametric models mentioned above.

In another example, the parametric model may be incorporated into thereconstruction process. In this case, it is not necessary to performreconstruction of intensities I(u,t) in overall volume and time and thenuse that information to extract time constants of biological processesk_(i)(u).

Instead, the imaging equation

${y_{n}(t)}\text{∼}{{Poisson}\left( \left\lbrack {\sum\limits_{u}{{\varphi_{n}(u)}{I\left( {u,t} \right)}}} \right\rbrack \right)}$may be explicitly replaced with the model of the intensities

${y_{n}(t)}\text{∼}{{Poisson}\left( \left\lbrack {\sum\limits_{u}{{\varphi_{n}(u)}{B(t)}*{F_{1}\left( {{k_{1}(u)},\tau} \right)}*{F_{2}\left( {{k_{2}(u)},\tau} \right)}}} \right\rbrack \right)}$(where y_(n)(t) is the number of photon measured from a viewing positionn with a probability function of the view ϕ_(n)(u)).

In this case, the reconstruction process (e.g. by Maximum-Likelihood,Expectation maximization, or other equation solving techniques) is usedto recover the best fitting values of k_(i)(u), instead of recoveringI(u,t) and then k_(i)(u).

In some embodiments of the present invention, the use of a cameradirectly intended to perform dynamic studies, the ability to avoidinterim recovery of intensities in 3D-overall volume in various timeperiods may be a benefit, as the design of the scanning is optimized forthe kinetic parameters reconstruction, and not necessarily to imagequality in each time point.

Active Vision

The camera of the present invention may further include active visionwhich relates to a method of radioactive-emission measurements of a bodystructure, comprising:

performing radioactive-emission measurements of the body structure, at apredetermined set of views;

analyzing the radioactive-emission measurements; and

dynamically defining further views for measurements, based on theanalyzing.

Active vision may be used, for example, to better define an edge, bychanging a view direction, to direct a saturating detecting unit awayfrom a hot spot, to change the duration at a certain location, when agreater number of counts are required, or when sufficient counts havebeen obtained.

Reconstruction Stabilizer

The method of reconstruction employed by the present invention mayfurther include a method for stabilizing the reconstruction of an imagedvolumetric region, comprising:

performing an analysis of the reliability of reconstruction of aradioactive-emission density distribution of said volumetric region fromradiation detected over a specified set of views; and

defining modifications to at least one of a reconstruction process and adata collection process to improve said reliability of reconstruction,in accordance with said analysis.

Additionally, the method may include calculating a measure of saidreliability of reconstruction, said measure of reliability ofreconstruction being for determining a necessity of performing saidmodifications.

Furthermore, the method may include:

providing a detection probability matrix defining a respective detectionprobability distribution of said volumetric region for each of saidviews; calculating the singular values of said detection probabilitymatrix;

identifying singular values as destabilizing singular values.

Additionally, the method may include calculating a condition number ofsaid probability matrix as a measure of said reliability ofreconstruction.

It will be appreciated that this approach may result in non-uniformvoxels, wherein voxel volumetric region may increase or decrease asnecessary to increase the reliability of the reconstruction

View Selection

The present invention further utilizes a method of optimal viewselection, as follows:

providing said volumetric region to be imaged;

modeling said volumetric region;

providing a collection of views of said model;

providing a scoring function, by which any set of at least one view fromsaid collection is scorable with a score that rates information obtainedfrom said volumetric region by said set;

forming sets of views and scoring them, by said scoring function; and

selecting a set of views from said collection, based on said scoringfunction for imaging said volumetric region.

Additionally, zooming in onto a suspected pathology may be performed bya two-step view selection, wherein once the suspected pathology isobserved, that region of the volumetric region is modeled anew and a newcollection of views is obtained specifically for the suspectedpathology.

Experimental Results

Reference is now made to FIGS. 9A-9J, which schematically illustratecardiac imaging of Tc-99m-Teboroxime, with the dynamic camera 10 inaccordance with aspects of the present invention. The significance ofthe experimental data provided herein is the ability to successfullyimage Teboroxime, which as FIG. 5B illustrates is washed out of the bodyvery quickly.

FIG. 9A provides anatomical landmarks, as follows:

-   -   Left Ventricle (LV)    -   Right Ventricle (RV)    -   Left Atrium (LA)    -   Right Atrium (RA)

FIG. 9B is a dynamic study input of bloodpool, mayocardium, and bodytimed activity.

FIG. 9C is a Film-stripe representation of a dynamic SPECT study, asfollows:

-   -   First 2 minutes after Tc99m-Teboroxime* injection, 10 s/frame    -   Mid-ventricular slices (upper row: SA lower row: HLA)

Note: as the intense blood pool activity at the center of the heartchambers gradually clears, while the myocardial uptake graduallyintensifies.

FIG. 9D is a Film-stripe representation of a dynamic SPECT study, asfollows:

-   -   First 4 minutes after Tc99m-Teboroxime* injection, 10 s/frame    -   Mid-ventricular slices (upper row: SA lower row: HLA)

Note: as the intense blood pool activity at the center of the heartchambers gradually clears, while the myocardial uptake graduallyintensifies

FIG. 9E is a Movie representation of a dynamic SPECT study (SA), asfollows:

-   -   First 4 minutes after Tc99m-Teboroxime* injection, 10 s/frame    -   Mid-ventricular SA slices.

Note: as the intense blood pool activity gradually clears in LV and RVcavities

Note: Myocardial uptake gradually intensifies, (the thin walled RV isless intense)

FIG. 9F is a Movie representation of a dynamic SPECT study (SA), asfollows:

-   -   First 4 minutes after Tc99m-Teboroxime* injection, 10 s/frame    -   Mid-ventricular SA slices.

Note: as the intense blood pool activity gradually clears in LV, RV, LAand RA cavities

Note: Myocardial uptake gradually intensifies, (the thin walled RV antatria are less intense)

FIG. 9G is a Movie representation of a dynamic SPECT study (fast).

FIG. 9H is a Movie representation of a dynamic SPECT study (slow).

FIG. 9I represents volumetric region segmentation for separate tissueflow dynamics measurement

FIG. 9J represents measured kinetic curves.

FIG. 10 is another experiment, illustrating time binning at a rate of0.001 seconds.

Electronic Scheme for Fast Throughput

High-sensitivity detecting units, such as the room temperature,solid-state CdZnTe (CZT) detectors utilized in the present embodiments,must be discharged frequently, as their high-sensitivity can lead torapid saturation. When a given detector saturates, the output count forthe associated pixel no longer accurately reflects the number ofincoming photons, but rather the maximum number that the detector iscapable of absorbing. This inaccuracy may lead to errors duringreconstruction. It is therefore important to perform readout oftenenough to avoid detector saturation.

The data channel from the assembly 20 (or the assembly 20 readoutcircuitry) to the signal processing components must be fast enough tohandle the large quantities of data which are obtained from thedetecting units 12.

The electronic scheme of the present embodiments preferably includes oneor more of the following solutions for performing frequent detector unitreadout, while maintaining high data throughput to prevent data channelsaturation.

In a preferred embodiment, the dynamic SPECT camera 10 includes aparallel readout unit for performing parallel readout of emission countdata. Parallel readout requires less time than serial readout (in whichthe pixels are read out in sequence), as multiple pixels may be read outin a single cycle without losing the information of the individual pixelcounts. The readout rate can thus be increased without loss of data.

Parallel readout may be performed at many levels. Reference is now madeto FIG. 11, which illustrates various levels of detector unitorganization at which parallel readout may be performed. The presentexemplary embodiment shows a single detector array 25, which includesthree assemblies 20. Each assembly includes a plurality of blocks 18 ofdetector units 12. Each detecting unit 12 includes a single-pixeldetector (FIG. 1D).

The parallel readout unit preferably performs parallel readout at thelevel of one or more of:

a) detecting units 12, each of the single-pixel detector 14;

b) blocks 18, which include a plurality of detecting units 12;

c) assemblies 20, which include a plurality of blocks 18

d) array 25, which includes a plurality of assemblies 20.

When the parallel readout unit performs parallel readout at the level ofthe detecting units 12, count values are read out in parallel from eachof the electrically insulated single-pixel detector 14. The single-pixeldetector 14 is discharged at readout, and the photon collection processbegins anew.

When the parallel readout unit performs parallel readout at the level ofthe block 18, count values from each of the detecting units 12 are readout serially, however multiple blocks 18 are read out in parallel. Thisapproach is less complex to implement than parallel readout of thedetecting units 12, although it results in a certain reduction inreadout rate to accommodate the serial readout. Again, the single-pixeldetectors 14 are discharged at readout.

Similarly, when the parallel readout unit performs parallel readout atthe level of the assembly 20, count values from each of the detectingunits 12 in the assembly 20 are read out serially, however multipleassemblies 20 are read out in parallel.

Parallel readout preferably includes multiple detection, amplificationand signal processing paths for each of the pixels, thereby avoidingsaturation due to a single localized high emission area—“hot spot”. Thisis in contrast with the Anger camera, in which multiple collimators areassociated with a single-pixel scintillation detector, and saturation ofthe scintillation detector may occur even due to a localized hot spot.

FIG. 12 illustrates an exemplary embodiment of parallel readout in thedynamic SPECT camera 10. Radioactive emissions are detected by pixelatedCZT crystals, where each crystal is divided into 256 pixels. The crystalis part of a ‘CZT MODULE’ (B) which also includes two ASICS eachreceiving events from 128 pixels. The ASIC is an OMS ‘XAIM3.4’ made byOrbotech Medical Systems, Rehovot, Israel, together with the CZTcrystal. The 2 ASICs share a common output and transmit the data to ‘ADCPCB’ (C) that handles four ‘CZT MODULES’ (B) in parallel. Thus, a totalof 1024 pixels are presently channeled through one ADC board. The systemis capable of further increasing the accepted event rate by channelingevery two ASICS through a single ADC. The ‘ADC PCB’ (C) transmits thedata to the ‘NRG PCB’ (D) that handles ten ‘ADC PCB’s (C) in parallel,but could be further replicated should one want to further decrease“dead time”. The ‘NRG PCB’ (D) transmits the data to the ‘PC’ (E) whereit is stored.

All in all, in the present embodiment, forty CZT MODULEs which contain atotal of 10240 pixels transmit in parallel to the PC.

The bottle neck, and hence the only constraint, of the system data flowis the ASICS in the ‘CZT MODULE’ (B) and the connection to the ‘ADCPCB’s (C):

1. An ASIC (128 pixels) can process one photon hit within 3.5 uSec, or285,000 events/sec over 128 pixels, i.e. over 2200 events/px/sec-anexceedingly high rate.

2. Two ASICS share the same output, and hence coincident event output ofthe two ASICS in a ‘CZT MODULE’ (B) will cause a collision andinformation loss. The duration of an event output from the ASIC is 1uSec.

When the readout is rapid, the rate at which the radiation emission datais read out of the single-pixel detectors 14 may be greater than therate at which it may be output to the processor. One known solution formanaging a difference data arrival and data processing rates is to use abuffer. The buffer provides temporary storage of the incoming data,which is retrieved at a later time.

A buffered readout configuration can result in the loss of timinginformation, unless active steps are taken to preserve the timeinformation associated with the collected emission data, for example, astaught hereinabove, under the heading, “The Timing Mechanism 30.”

In accordance with embodiments of the present invention, timinginformation is preserved. The electrical scheme may include a bufferwhich stores emission data along with timing information for each dataitem or group of data items (in the case where emission data fromseveral detectors was obtained at substantially the same time, forexample due to parallel readout), and an identification of theassociated detector unit. Utilizing a buffer ensures that emission datamay be collected from the detectors frequently enough to avoidsaturation, even when the data channel throughput is limited. In stopand shoot mode, for example, the emission count data may be stored inthe buffer for retrieval while the detector head is moving to the nextlocation. Accurate reconstruction may thus be performed.

The camera readout circuitry is preferably designed to provide fastreadout and detecting unit discharge. Fast readout circuitry may includefast analog and digital circuitry, fast A/D converters, pipelinedreadout, and so forth.

After the emission data has been read out of the single-pixel detectors14, it may be necessary to convey the data to a processor forreconstruction as a single or limited number of data streams. The cameraelectronic scheme may include a multiplexer, for combining two or moreemission data streams into a single data stream. The emission data maythus be conveyed to the processor over one physical link (or alternatelyover a reduced number of parallel links). For each radioactive emissionevent, the multiplexer includes both the timing information and anidentification of the single-pixel detector 14 supplying the event. Themultiplexed data may later be de-multiplexed by the processor, andreconstruction may be performed with complete information for each dataitem, including for example, total counts per single-pixel detector 14,per time bin, single-pixel detector location and orientation, and thetime bin. Parallel readout may thus be performed, even when thecollected data is to be output over a single data link.Sensitivity Consideration.

It will be appreciated that dynamic imaging with a SPECT camera has beenattempted in the past, unsuccessfully, primarily, because prior-artSPECT cameras are not sensitive enough to provide tomographicreconstruction images, for example, of a heart, with sufficient objectresolution, for example, 10×10×10 cubic millimeters, in less than aminute.

As a case in point, U.S. Pat. No. 7,026,623, to Oaknin, et al., filed onJan. 7, 2004, issued on Apr. 11, 2006, and entitled, “Efficient singlephoton emission imaging,” describes a method of diagnostic imaging in ashortened acquisition time for obtaining a reconstructed diagnosticimage of a portion of a body of a human patient who was administeredwith dosage of radiopharmaceutical substance radiating gamma rays, usingan Anger Camera and SPECT imaging. The method includes effectiveacquisition times from less than 14 minutes to less than 8 minutes.Oaknin, et al., do not claim an effective acquisition time of less than7 minutes. Yet, in view of the section entitled, “Time ScaleConsiderations,” hereinabove, a sampling rate of 8 about minutes is fartoo slow for myocardial perfusion studies, where a sampling rate of atleast two tomographic reconstruction images per heartbeat, that is,about every 30 seconds, is desired, and furthermore, where processesoccur at rates of several seconds, and must be sampled at rates of asecond or less, as seen in FIG. 5B.

The dynamic SPECT camera 10 in accordance with embodiments of thepresent invention achieves sensitivity sufficient for the requiredsampling rates of between every 30 seconds and every half a second, bycombining several features, specifically intended to increasesensitivity, as follows:

a collimator 16 with a solid collection angle δ of at least 0.005steradians or greater, for a fast collection rate, and high sensitivity,wherein the loss in resolution is compensated by one or a combination ofthe following factors:

i. motion in a stop and shoot acquisition mode, at very smallincremental steps, of between about 0.01 degrees and about 0.75 degrees.

ii. simultaneous acquisition by the assemblies 20, each scanning thesame region of interest from a different viewing position, thusachieving both shorter acquisition time and better edge definitions.

iii. the structure 15 conforming to the body contours, for acquisitionwith substantial contact or near contact with the body.

Definition of a Clinically-Valuable Image

In consequence, the dynamic SPECT camera 10 is capable of producing a“clinically-valuable image” of an intra-body region of interest (ROI)containing a radiopharmaceutical, while fulfilling one or more of thefollowing criteria:

1. the dynamic SPECT camera 10 is capable of acquiring at least one of5000 photons emitted from the ROI during the image acquisitionprocedure, such as at least one of 4000, 3000, 2500, 2000, 1500, 1200,1000, 800, 600, 400, 200, 100, or 50 photons emitted from the ROI. Inone particular embodiment, the camera is capable of acquiring at leastone of 2000 photons emitted from the ROI during the image acquisitionprocedure;2. the dynamic SPECT camera 10 is capable of acquiring at least 200,000photons, such as at least 500,000, 1,000,000, 2,000,000, 3,000,000,4,000,000, 5,000,000, 8,000,000, or 10,000,000 photons, emitted from aportion of the ROI having a volume of no more than 500 cc, such as avolume of no more than 500 cc, 400 cc, 300 cc, 200 cc, 150 cc, 100 cc,or 50 cc. In one particular embodiment, the camera is capable ofacquiring at least 1,000,000 photons emitted from a volume of the ROIhaving a volume of no more than 200 cc;3. the dynamic SPECT camera 10 is capable of acquiring an image of aresolution of at least 7×7×7 mm, such as at least 6×6×6 mm, 5×5×5 mm,4×4×4 mm, 4×3×3 mm, or 3×3×3 mm, in at least 50% of the reconstructedvolume, wherein the radiopharmaceutical as distributed within the ROIhas a range of emission-intensities I (which is measured as emittedphotons/unit time/volume), and wherein at least 50% of the voxels of thereconstructed three-dimensional emission-intensity image of the ROI haveinaccuracies of less than 30% of range I, such as less than 25%, 20%,15%, 10%, 5%, 2%, 1%, or 0.5% of range I. For example, theradiopharmaceutical may emit over a range from 0 photons/second/cc to10{circumflex over ( )}5 photons/second/cc, such that the range I is10{circumflex over ( )}5 photons/second/cc, and at least 50% of thevoxels of the reconstructed three-dimensional intensity image of the ROIhave inaccuracies of less than 15% of range I, i.e., less than 1.5×10⁴photons/second/cc. For some applications, the study produce a parametricimage related to a physiological process occurring in each voxel. In oneparticular embodiment, the image has a resolution of at least 5×5×5 mm,and at least 50% of the voxels have inaccuracies of less than 15% ofrange I;4. the dynamic SPECT camera 10 is capable of acquiring an image, whichhas a resolution of at least 7×7×7 mm, such as at least 6×6×6 mm, 5×5×5mm, 4×4×4 mm, 4×3×3 mm, or 3×3×3 mm, in at least 50% of thereconstructed volume, wherein the radiopharmaceutical as distributedwithin the ROI has a range of emission-intensities I (which is measuredas emitted photons/unit time/volume), and wherein at least 50% of thevoxels of the reconstructed three-dimensional emission-intensity imageof the ROI have inaccuracies of less than 30% of range I, such as lessthan 25%, 20%, 15%, 10%, 5%, 2%, 1%, or 0.5% of range I. For example,the radiopharmaceutical may emit over a range from 0 photons/second/ccto 10⁵ photons/second/cc, such that the range I is 10⁵photons/second/cc, and at least 50% of the voxels of the reconstructedthree-dimensional intensity image of the ROI have inaccuracies of lessthan 15% of range I, i.e., less than 1.5×10⁴ photons/second/cc. For someapplications, the study produces a parametric image related to aphysiological process occurring in each voxel. In one particularembodiment, the image has a resolution of at least 5×5×5 mm, and atleast 50% of the voxels have inaccuracies of less than 15% of range I;5. the dynamic SPECT camera 10 is capable of acquiring an image, whichhas a resolution of at least 20×20×20 mm, such as at least 15×15×15 mm,10×10×10 mm, 7×7×7 mm, 5×5×5 mm, 4×4×4 mm, 4×3×3 mm, or 3×3×3 mm,wherein values of parameters of a physiological process modeled by aparametric representation have a range of physiological parameter valuesI, and wherein at least 50% of the voxels of the reconstructedparametric three-dimensional image have inaccuracies less than 100% ofrange I, such as less than 70%, 50%, 40%, 30%, 25%, 20%, 15%, 10%, 5%,2%, 1%, or 0.5% of range I. For example, the physiological process mayinclude blood flow, the values of the parameters of the physiologicalprocess may have a range from 0 to 100 cc/minute, such that the range Iis 100 cc/minute, and at least 50% of the voxels of the reconstructedparametric three-dimensional image have inaccuracies less than 25% ofrange I, i.e., less than 25 cc/minute. In one particular embodiment, theimage has a resolution of at least 5×5×5 mm, and at least 50% of thevoxels have inaccuracies of less than 25% of range I; and/or6. the dynamic SPECT camera 10 is capable of acquiring an image, whichhas a resolution of at least 7×7×7 mm, such as at least 6×6×6 mm, 5×5×5mm, 4×4×4 mm, 4×3×3 mm, or 3×3×3 mm, in at least 50% of thereconstructed volume, wherein if the radiopharmaceutical is distributedsubstantially uniformly within a portion of the ROI with anemission-intensity I+/−10% (which is defined as emitted photons/unittime/volume), and wherein at least 85% of the voxels of thereconstructed three-dimensional emission-intensity image of the portionof the ROI have inaccuracies of less than 30% of intensity I, such asless than 15%, 10%, 5%, 2%, 1%, 0.5%, 20%, or 25% of intensity I. Forexample, the radiopharmaceutical may be distributed within a volumetricregion with a uniform emission-intensity I of 10{circumflex over ( )}5photons/second/cc, and at least 85% of the voxels of the reconstructedthree-dimensional intensity image of the volumetric region haveinaccuracies of less than 15% of intensity I, i.e., less than 1.5×10⁴photons/second/cc. For some applications, the same definition may applyto a study which produces a parametric image related to a physiologicalprocess occurring in each voxel. In one particular embodiment, the imagehas a resolution of at least 5×5×5 mm, and at least 50% of the voxelshave inaccuracies of less than 15% of intensity I.

It is expected that during the life of this patent many relevant dynamicSPECT cameras will be developed and the scope of the term dynamic SPECTcamera is intended to include all such new technologies a priori.

As used herein the term “substantially” refers to ±10%.

As used herein the term “about” refers to ±30%.

Additional objects, advantages, and novel features of the presentinvention will become apparent to one ordinarily skilled in the art uponexamination of the following examples, which are not intended to belimiting. Additionally, each of the various embodiments and aspects ofthe present invention as delineated hereinabove and as claimed in theclaims section below finds experimental support in the followingexamples.

It is appreciated that certain features of the invention, which are, forclarity, described in the context of separate embodiments, may also beprovided in combination in a single embodiment. Conversely, variousfeatures of the invention, which are, for brevity, described in thecontext of a single embodiment, may also be provided separately or inany suitable subcombination.

Although the invention has been described in conjunction with specificembodiments thereof, it is evident that many alternatives, modificationsand variations will be apparent to those skilled in the art.Accordingly, it is intended to embrace all such alternatives,modifications and variations that fall within the spirit and broad scopeof the appended claims. All publications, patents and patentapplications mentioned in this specification are herein incorporated intheir entirety by reference into the specification, to the same extentas if each individual publication, patent or patent application wasspecifically and individually indicated to be incorporated herein byreference. In addition, citation or identification of any reference inthis application shall not be construed as an admission that suchreference is available as prior art to the present invention.

It is expected that during the life of this patent many relevant devicesand systems will be developed and the scope of the terms herein,particularly of the terms SPECT detectors, processing unit,communication, and images are intended to include all such newtechnologies a priori.

It is appreciated that certain features of the invention, which are, forclarity, described in the context of separate embodiments, may also beprovided in combination in a single embodiment. Conversely, variousfeatures of the invention, which are, for brevity, described in thecontext of a single embodiment, may also be provided separately or inany suitable subcombination.

Although the invention has been described in conjunction with specificembodiments thereof, it is evident that many alternatives, modificationsand variations will be apparent to those skilled in the art.Accordingly, it is intended to embrace all such alternatives,modifications and variations that fall within the spirit and broad scopeof the appended claims. All publications, patents, and patentapplications mentioned in this specification are herein incorporated intheir entirety by reference into the specification, to the same extentas if each individual publication, patent or patent application wasspecifically and individually indicated to be incorporated herein byreference. In addition, citation or identification of any reference inthis application shall not be construed as an admission that suchreference is available as prior art to the present invention.

What is claimed is:
 1. A method for reconstructing a radioactiveemission image of an overall volume in a human body having first andsecond volumetric regions, each volumetric region having respectivelyindependent dynamic characteristics, the method comprising: a) obtaininga structural image of the overall volume in the human body, includingsaid volumetric regions; b) delineating said structural image of theoverall volume including said first and second volumetric regions, todelineate said first and second volumetric regions-; c) obtainingradioactive emissions from the overall volume in the human body,including said volumetric regions and including timing data, using aplurality of detectors each performing oscillatory motion; d)reconstructing, using said radioactive emissions, a series of 3D imageswith time by: separately reconstructing said first volumetric region andsaid second volumetric region using said timing data, where differentgating is employed for said first and said second volumetric regions,said different gating according to said respectively independent dynamiccharacteristics; and using a model for at least one of said volumetricregions, said model describing a relationship, with time, for said atleast one volumetric region, between radioactive emission intensitiesand one or more of: concentration of radioactive tracer in the blood,uptake time constant of the tissue and washout time constant of thetissue.
 2. The method of claim, 1 wherein said separately reconstructingis an iterative process including using object implantation for refiningreconstruction of at least one of the first and second volumetricregions.
 3. The method of claim 2, wherein at least one of thevolumetric regions comprises at least a part of a body organ or otherbody portion; and wherein said object implantation includes: providing amodel of only a part of said overall volume in the human body, saidmodel comprising a general location and shape of, and expected number ofphotons emitted from, said body organ or said at least part of bodyportion; replacing, at a general location in said initial radioactiveemission image corresponding to said model general location, initialradioactive emission image voxels with said model general shape andinitial radioactive emission image voxel photon counts, based on saidexpected number of photons from said model, where said replacing is oneor more times during said iterative process, each time for providing abetter starting point for performing next iteration of saidreconstruction of at least one of the first and second volumetricregions.
 4. The method of claim 1, wherein said obtaining radioactiveemissions further includes obtaining timing data by a method selectedfrom the group consisting of time stamping, time binning, and acombination thereof.
 5. The method of claim 4, wherein said separatelyreconstructing includes separately reconstructing said first and secondvolumetric regions according to said respectively independent dynamiccharacteristics of said timing data.
 6. The method of claim 4, whereinsaid timing data comprises first timing data for said first volumetricregion and second timing data for said second volumetric region; whereinsaid separately reconstructing comprises: reconstructing said firstvolumetric region using said first timing data; and reconstructing saidsecond volumetric region using said second timing data.
 7. The method ofclaim 6, including: obtaining a second set of radioactive emissions fromthe overall volume in the human body, including said volumetric regions,after the reconstructing the initial radioactive emission image, thesecond set including timing data, wherein said separately reconstructingincludes separately reconstructing said first and second volumetricregions according to said respectively independent dynamiccharacteristics, from said second set.
 8. The method of claim 7, whereinsaid first and second volumetric regions have higher dynamic activitythan surrounding tissue; wherein obtaining a second set of radioactiveemissions, further includes independently directing detecting resourcesto said first and second volumetric regions, so as to concentratedetecting resources on the volumetric region of greater dynamicactivity.
 9. The method of claim 1, wherein separately reconstructingfurther includes independently carrying reconstruction of said first andsecond volumetric regions, to different levels of accuracy, so as toconcentrate reconstruction resources on a volumetric region of greaterdynamic activity.
 10. The method of claim 1, wherein said firstvolumetric region confines a human heart.
 11. The method of claim 1,wherein said volumetric regions comprises independent sub-volumetricregions, wherein during said separately reconstructing, each one of saidindependent sub-volumetric regions is reconstructed separately.
 12. Themethod of claim 1, wherein said radioactive emissions are obtained usinga single photon emission computed tomography (SPECT) camera.
 13. Themethod of claim 12, wherein said SPECT camera comprises a plurality ofdetecting units.
 14. The method of claim 13, wherein time binning isindependently enabled to each detecting unit from said plurality ofdetecting units.
 15. The method of claim 13, wherein time binning isindependently enabled to one or more sub-groups of said plurality ofdetecting units from said plurality of detecting units.
 16. The methodof claim 13, wherein each said detecting unit includes: a single-pixeldetector, for detecting radioactive emissions; and a dedicatedcollimator, attached to the single-pixel detector, at the proximal endthereof, for defining a solid collection angle δ for the detecting unit.17. The method of claim 1, wherein said separately reconstructingcomprises reconstructing an initial radioactive emission image which isrepresented by a system of voxels.
 18. The method of claim 17, furthercomprising: constructing an anatomical construction of voxels, for saidsystem of voxels, in which voxel boundaries are aligned with boundariesof structural objects of said first volumetric region, based on saidstructural image, said separately reconstructing being based on saidanatomical construction of voxels.
 19. The method of claim 18, whereinthe anatomical construction of voxels includes voxels of varyingvolumetric regions, depending on their anatomic position and relevance.20. The method of claim 1, wherein said structural image is provided bya source, selected from the group consisting of 2-D ultrasound, 3-Dultrasound, planner x-rays, CT x-rays, MRI, and an anatomical atlas. 21.The method of claim 1, wherein said obtaining radioactive emissionscomprises time binning said radioactive emissions using different timebin lengths for said first and said second volumetric regions.
 22. Themethod of claim 1, wherein said obtaining a structural image of theoverall volume includes obtaining the structural image of the overallvolume, including the separate volumetric regions, wherein the firstvolumetric region has a first amount of dynamic activity and the secondvolumetric region has a second amount of dynamic activity, and whereinthe first volumetric region moves in the overall volume relative to thesecond volumetric region.
 23. The method of claim 1 comprising, aftersaid separately reconstructing, repeating said separately reconstructinguntil a desired quality of reconstruction of the overall volume has beenreached.
 24. The method of claim 23, wherein it is determined that thedesired quality of reconstructions of the overall volume has beenreached when a number of gated voxels with activity is above apredefined threshold.
 25. The method of claim 1, wherein said separatelyreconstructing includes separately reconstructing said first volumetricregion and reconstructing said second volumetric region according tosaid respectively independent dynamic characteristics of said respectivefirst and second volumetric regions; wherein said method furtherincludes combining said first and second reconstructed volumetricregions into a single image.
 26. The method of claim 1, wherein saidseparately reconstructing comprises using at least two different saidmodels for different portions of said at least one of said volumetricregions.
 27. The method of claim 1, wherein said structural image is afirst reconstruction based on said radioactive emissions of said overallvolume.
 28. The method of claim 1, wherein said model describes arelationship, between radioactive emission intensities and concentrationof radioactive tracer in the blood, uptake time constant of the tissue,and washout time constant of the tissue.
 29. The method of claim 1,wherein said using said model comprises generating, for said at leastone volumetric region, a three dimensional relationship with timebetween said radioactive emission intensities and said one or more of:concentration of radioactive tracer in the blood, uptake time constantof the tissue and washout time constant of the tissue.